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Preface | ||
Towards rational design of AMPA receptor ligands: an integrated medicinal, computational, biostructural and molecular pharmacological approach | 1 | |
From heparin to synthetic antithrombotics. The pentasaccharide story and follow-up | 13 | |
A new future for synthesis? | 21 | |
Directed evolution of enantioselective enzymes as catalysts in the production of chiral pharmaceuticals | 27 | |
At the interface of organic synthesis and biosynthesis | 39 | |
What can structure tell us about function in the estrogen receptors? | 53 | |
Molecular docking and dynamics simulations in the ligand binding domain of steroid hormone receptors | 57 | |
Peroxisome proliferator-activated receptors and reverse endocrinology | 67 | |
Biomolecular mass spectrometry related to drug research | 81 | |
Chemical and biological diversity in drug discovery | 95 | |
Muscarine acetylcholine receptor knockout mice: phenotypical analysis and clinical implications | 97 | |
Changes in expression of the orphan G-protein coupled receptor GPR7 in human painful peripheral neuropathies | 115 | |
Computational methods for the analysis of molecular diversity | 125 | |
Enhancing drug discovery by acquisition of chemical diversity | 135 | |
Chemical diversity as a driving force to design and put in practice synthetic strategies leading to combinatorial libraries for lead discovery and lead optimization | 147 | |
Beyond G proteins: the role of accessory proteins in G protein-coupled receptor signalling | 161 | |
Mechanisms of action of antipsychotic drugs: the role of inverse agonism at the D[subscript 2] dopamine receptor | 175 | |
Agonist channeling of [alpha][subscript 2]-adrenoceptor function | 181 | |
Antibacterials as wonder drugs and how their effectiveness is being compromised | 193 | |
Pseudomonas aeruginosa quorum sensing: a target for antipathogenic drug discovery | 207 | |
Discovery and development of new anti-bacterial drugs | 213 | |
Discovery of small molecule insulin mimetics as potential novel antidiabetic agents | 227 | |
Expression databases for pharmaceutical lead optimisation | 237 | |
New developments in the pharmacology of cannabinoids | 249 | |
Author index | 259 | |
Subject index | 261 |
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