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Dedication | ||
Preface | ||
Participants | ||
Contributors | ||
Opening Remarks | ||
Symposium Presentation: Diethylstilbestrol (DES) Syndrome: Present Status of Animal and Human Studies | 1 | |
Introduction: Androgen Receptors and Regulation of Androgen Action in Normal and Abnormal Cells | 11 | |
The Conjoint Actions of Androgens and Estrogens in the Induction of Proliferative Lesions in the Rat Prostate | 18 | |
Enhancement of Prostate Carcinogenesis in Rats by Testosterone and Prolactin | 27 | |
Hormonal Carcinogenesis in Syrian Hamsters: A Hypothesis Involving Glutathione S-Transferase Regulation | 33 | |
Introduction: Current Concepts of Sex Hormone Action (An Overview) | 43 | |
Control of Uterine Epithelial Growth and Differentiation: Implications for Estrogen-Associated Neoplasia | 51 | |
A Novel Protein Kinase Activity Identified from Human Breast Cancer Cell Lines | 58 | |
Estrous Cycle Modification of Rat Mammary Carcinoma Induction | 65 | |
Hormones, Cell Proliferation, and Mammary Carcinogenesis | 73 | |
Introduction: Factors Influencing the Metabolism and Action of Estradiol | 81 | |
Interactions of Carcinogenic Estrogens with Microtubular Proteins | 86 | |
Differential Interactions of Estradiol Metabolites with the Estrogen Receptor: Genomic Consequences and Tumorigenesis | 95 | |
Oxidation of Estrogens and Other Steroids by Cytochrome P-450 Enzymes: Relevance to Tumorigenesis | 104 | |
Metabolism of Moxestrol in the Hamster Kidney: Significance for Estrogen Carcinogenesis | 110 | |
Introduction: Inhibition of Tumor Promotion by Antihormonal Agents | 121 | |
Sexual Dimorphism of Hepatic Steroid Metabolism and Its Significance for Chemical Hepatocarcinogenesis | 124 | |
Growth Stimulation and Tumor Promotion in Rat Liver by Ethynyl Estradiol and Other Estrogens | 130 | |
Growth Factors in Murine Mammary Adenocarcinomas Induced by Progestins | 138 | |
The Influence of Steroid Hormones and Antihormones on the Growth and Differentiation of Normal Human Breast Cells in Culture | 145 | |
Introduction: Molecular Mechanisms of Hormonal Carcinogenesis | 159 | |
The v-raf and Ha-ras Oncogenes Inhibit Transcription from the Beta-Casein Gene Promoter by Suppression of a Mammary Gland Specific Transcription Factor | 164 | |
Functional Aspects of EGF-Like Peptides in Ovarian-Steroid Responsive Organs | 172 | |
Androgen Regulation of Growth Factor and Early Growth Response Gene Expression in Hamster DDT1-MF2 and Human Prostate LNCAP Cells | 182 | |
Estrogen Regulation of Protooncogene Expression | 193 | |
Introduction: Receptor-Mediated Carcinogenesis: Implications for Carcinogenic Risk of Sex Hormones | 203 | |
Endogenous Estrogen and Progesterone as the Major Determinants of Breast Cancer Risk: Prospects for Control by 'Natural' and 'Technological' Means | 209 | |
Synthetic Estrogens and Liver Cancer: Risk Analysis of Animal and Human Data | 217 | |
Carcinogenic Risk Assessment of Steroid Hormone Exposure in Relation to Prostate Cancer Risk | 225 | |
Hormonal Carcinogenesis - Future Perspectives | 237 | |
Cytogenetic Changes in Renal Neoplasms and During Estrogen-Induced Renal Tumorigenesis in Hamsters | 247 | |
Pituitary Regulation of Sex-Differentiated Promotion of Rat Liver Carcinogenesis | 251 | |
Modulation of Estrogen Metabolism by Inducers of P-4501A2: Possible Application to the Chemoprevention of Breast Cancer | 254 | |
Estrogen Metabolism in Subcellular Preparations and Tissue Culture of Syrian Hamster Liver and Kidney | 259 | |
Hormonal Regulation of Plasminogen Activation in the Human Endometrium | 263 | |
Your Research - Our Lives | 268 | |
Prostaglandin H Synthase Peroxidase Catalyzed Metabolism of Estrogens in Syrian Hamster and Rabbit Kidney | 272 | |
Peroxidative Metabolism of Diethylestilbestrol in Ram Seminal Vesicle Cell Cultures: An In-Vitro Model for Studies of Estrogen-Induced Genotoxicity | 274 | |
In Vivo Effects of Progesterone on Human Breast 17[beta]-Dehydrogenase and Epithelial Cells Mitotic Activities | 277 | |
DNA Adduct Profiles in Hamster Kidney Following Chronic Exposure to Various Carcinogenic and Noncarcinogenic Estrogens | 280 | |
Hormone-Dependent Activation of c-Ki-ras in N-Methyl-N-Nitrosourea (MNU)-Induced Mouse Mammary Tumors | 285 | |
Growth Hormone Regulation of the c-myc Gene During Sex-Differentiated Rat Liver Carcinogenesis | 288 | |
Fetal Stromal Cells Produce a TGF that Elicits Hyperplasia in Adult Mammary Epithelium | 292 | |
Induction of Catechol Estrogen Formation by Indole-3-Carbinol | 296 | |
Cytochrome P-450 Mediated Activation and Irreversible Binding of Tamoxifen to Rat and Human Liver Proteins | 300 | |
Neonatal Diethylstilbestrol Prevents Spontaneously Developing Mammary Tumors | 305 | |
Hormone-Dependent Uterine Adenocarcinoma Following Developmental Treatment with Diethylstilbestrol: A Murine Model for Hormonal Carcinogenesis | 309 | |
Effects of Steroidal and Stilbene Estrogens and Their Peroxidative Metabolites on Microtubular Proteins | 313 | |
Properties of Micronuclei Induced by Various Estrogens in Two Different Mammalian Cell Systems | 318 | |
High-Performance Liquid Chromatography Method for the Separation of Potential Metabolites of Estradiol | 323 | |
Ovarian Hormones Enhance the Carcinogenic Activity of 2,3,7,8-TCDD in Rats | 326 | |
Index | 331 |
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