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Foreword | ix | |
Introduction | xi | |
List of Tables | xiii | |
List of Figures | xv | |
Part I | Basics of Genetics and Human Genetics | 1 |
1 | Human Genetic Disease | 3 |
2 | Introduction to Basic and Molecular Information | 13 |
3 | Human Variation and Its Applications | 31 |
4 | Gene Action and Patterns of Inheritance | 43 |
Part II | Major Genetic Disorders | 75 |
5 | Cytogenetic Disorders | 77 |
6 | Inherited Biochemical Disorders | 119 |
7 | Birth Defects and Congenital Anomalies | 141 |
Part III | Assessing and Intervening with Clients and Families at Genetic Risk | 155 |
8 | Impact of Genetic Diseases on the Family Unit | 157 |
9 | Assessment of Genetic Disorders | 191 |
10 | Genetic Counseling | 213 |
11 | Genetic Testing and Screening | 231 |
12 | Prenatal Detection and Diagnosis | 271 |
13 | The Vulnerable Fetus | 295 |
14 | Reproductive and Genetic Effects of Environmental Chemicals and Agents | 329 |
15 | Therapeutic Modalities | 345 |
Part IV | The Role of Genetics in Common Situations, Conditions, and Diseases | 361 |
16 | Genetics and the Common Diseases: Methods, Problems, and Pitfalls | 363 |
17 | Twins and Twin Studies | 367 |
18 | Drug Therapy and Genetics (Pharmacogenetics) | 373 |
19 | Genetics and the Immune System | 387 |
20 | Mental Retardation | 401 |
21 | Aging, Longevity, and Alzheimer Disease | 411 |
22 | Emphysema, Liver Disease, and Alpha-1-Antitrypsin Deficiency | 419 |
23 | Cancer | 425 |
24 | Diabetes Mellitus | 449 |
25 | Mental Illness and Behavior | 459 |
26 | Heart Disease | 467 |
Part V | In Closing | 479 |
27 | Genes, Ethics, and Future Generations | 481 |
Glossary | 489 | |
Appendix | Organizations and Groups Providing Information, Products, and Services for Genetic Conditions | 497 |
Index | 527 |
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