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Preface | ||
Physiological modeling of the small intestine in drug absorption | 3 | |
Intracellular metabolism of Lamivudine | 33 | |
Mechanism-based pharmacodynamic modeling for prediction of exposure response | 49 | |
Mechanism-based PK/PD modeling of Digoxin : role of receptor heterogeneity and postreceptor events | 67 | |
Pharmacodynamics and pharmacogenomics of corticosteroids : microarray studies | 85 | |
Bayesian inference in physiologically-based pharmacokinetic modeling : application to anticancer drug development | 105 | |
Monte Carlo parametric expectation maximization (MC-PEM) method of analyzing population pharmacokinetic/pharmacodynamic data | 135 | |
Application of Markov chain Monte Carlo methods to inverse problems in PK/PD | 165 | |
Regenerative Markov chain Monte Carlo methods for pharmacokinetic/pharmacodynamic estimation | 179 | |
Vizstruct : a multidimensional visualization algorithm for gene expression | 197 | |
Modeling and simulation of effects of adherence, pharmacokinetic, and pharmacodynamic characteristics in development of resistance to HIV regimens in treatment-naive patients | 211 | |
Mechanistic PK/PD modeling of antiretroviral therapies in AIDS clinical trials | 221 | |
Dose individualization for high-dose anti-cancer chemotherapy | 239 | |
Toward model-based chemotherapy treatment design | 255 | |
Control of uncertain pharmacodynamic systems | 275 | |
Contributors | 295 | |
Participants | 305 | |
Index | 317 |
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