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Preface vii
Biochemical, Cellular, and Molecular Functioning of the Heart
Introduction to Post-Genomic Cardiology 3
Molecular and Biochemical Methodology in the Post-Genomic Era 11
Cardiovascular Gene Expression 27
Cellular Techniques 51
Cardiovascular Signaling Pathways 77
Pediatric Cardiology in the Post-Genomic Era
Cardiac Development: Molecular and Genetic Analysis 117
Congenital and Acquired Heart Disease 165
Post-Genomic Analysis of Coronary Artery Disease, Angiogenesis, and Hypertension
Molecular Basis of Lipoprotein Disorders, Atherogenesis, and Thrombosis 211
Ischemia and Myocardial Infarction: A Post-Genomic Analysis 261
Cellular Pathways and Molecular Events in Cardioprotection 281
Cardiac Neovascularization: Angiogenesis, Arteriogenesis, and Vasculogenesis 315
Systemic and Pulmonary Hypertension 341
Post-Genomic Analysis of the Myocardium
Cardiomyopathies 363
Heart Response to Inflammation and Infection 415
The Failing Heart
Molecular Analysis of Heart Failure and Remodeling 441
Molecular and Genetic Analysis of Metabolic Disorders
Fatty Acid and Glucose Metabolism in Cardiac Disease 473
Molecular Genetics ofDysrhythmias
Dysrhythmias and Sudden Death 513
Genes, Gender, and Environment
Gender and Cardiovascular Disease 555
Aging and the Cardiovascular System
The Aging Heart: A Post-Genomic Appraisal 579
Looking to the Future
Future of Post-Genomic Cardiology 619
Section XI
Glossary 639
Index 657
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