First Issue | Marvel Knights Spider-Man is a Marvel comic book that contains material taking place within the mainstream Marvel Universe (Earth-616).
The Marvel Universe is the shared fictional universe where stories in most comic book titles and other media published by Marvel Entertainment take place, including those featuring Marvel's most familiar characters, such as Spider-Man, the Hulk, the X-Men, and the Avengers.
The Marvel Universe is further depicted as existing within a "multiverse" consisting of thousands of separate universes, all of which are the creations of Marvel Comics and all of which are, in a sense, "Marvel universes". In this context, "Marvel Universe" is taken to refer to the mainstream Marvel continuity, which is known as Earth-616.
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