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Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix Book

Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix
Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix, , Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix has a rating of 3.5 stars
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Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix, , Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix
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  • Statistical Mechanics and Stability of Macromolecules: Application to Bond Disruption, Base Pair Separation, Melting, and Drug Dissociation of the DNA Double Helix
  • Written by author Earl Prohofsky
  • Published by Cambridge University Press, July 2005
  • This book develops a statistical, mechanical analysis of the stability of macromolecules when melting. Booknews Develops a statistical mechanical analysis of the stability of biological macromolecules that is valid both for the long time s
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Book Categories

Authors

Preface
1Introduction1
2Macromolecular stability17
3Lattice dynamics47
4Effective phonon theory60
5Premelting disrupted chemical bonds78
6Cooperative melting88
7Strained chemical bonds: salt and pressure effects103
8Bond disruption and conformation change: B to Z conformation change in DNA117
9Hydration effects: structural water127
10Helix with daunomycin intercalated: increased helix stability and daunomycin-DNA binding constant137
11Nonrepeating DNA146
12Cutting and splicing: junctions, inserts, and the replicating fork159
13Interaction between a helix and a single attached molecule173
14Energy considerations in bond opening181
Appendix 1. Helical lattice dynamics193
Appendix 2. Density matrix and effective phonon theory199
Appendix 3. Green functions206
References214
Index223


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