Market analysis Book

	Dedication
	Preface
	Participants
	Contributors
	Opening Remarks
	Symposium Presentation: Diethylstilbestrol (DES) Syndrome: Present Status of Animal and Human Studies	1
	Introduction: Androgen Receptors and Regulation of Androgen Action in Normal and Abnormal Cells	11
	The Conjoint Actions of Androgens and Estrogens in the Induction of Proliferative Lesions in the Rat Prostate	18
	Enhancement of Prostate Carcinogenesis in Rats by Testosterone and Prolactin	27
	Hormonal Carcinogenesis in Syrian Hamsters: A Hypothesis Involving Glutathione S-Transferase Regulation	33
	Introduction: Current Concepts of Sex Hormone Action (An Overview)	43
	Control of Uterine Epithelial Growth and Differentiation: Implications for Estrogen-Associated Neoplasia	51
	A Novel Protein Kinase Activity Identified from Human Breast Cancer Cell Lines	58
	Estrous Cycle Modification of Rat Mammary Carcinoma Induction	65
	Hormones, Cell Proliferation, and Mammary Carcinogenesis	73
	Introduction: Factors Influencing the Metabolism and Action of Estradiol	81
	Interactions of Carcinogenic Estrogens with Microtubular Proteins	86
	Differential Interactions of Estradiol Metabolites with the Estrogen Receptor: Genomic Consequences and Tumorigenesis	95
	Oxidation of Estrogens and Other Steroids by Cytochrome P-450 Enzymes: Relevance to Tumorigenesis	104
	Metabolism of Moxestrol in the Hamster Kidney: Significance for Estrogen Carcinogenesis	110
	Introduction: Inhibition of Tumor Promotion by Antihormonal Agents	121
	Sexual Dimorphism of Hepatic Steroid Metabolism and Its Significance for Chemical Hepatocarcinogenesis	124
	Growth Stimulation and Tumor Promotion in Rat Liver by Ethynyl Estradiol and Other Estrogens	130
	Growth Factors in Murine Mammary Adenocarcinomas Induced by Progestins	138
	The Influence of Steroid Hormones and Antihormones on the Growth and Differentiation of Normal Human Breast Cells in Culture	145
	Introduction: Molecular Mechanisms of Hormonal Carcinogenesis	159
	The v-raf and Ha-ras Oncogenes Inhibit Transcription from the Beta-Casein Gene Promoter by Suppression of a Mammary Gland Specific Transcription Factor	164
	Functional Aspects of EGF-Like Peptides in Ovarian-Steroid Responsive Organs	172
	Androgen Regulation of Growth Factor and Early Growth Response Gene Expression in Hamster DDT1-MF2 and Human Prostate LNCAP Cells	182
	Estrogen Regulation of Protooncogene Expression	193
	Introduction: Receptor-Mediated Carcinogenesis: Implications for Carcinogenic Risk of Sex Hormones	203
	Endogenous Estrogen and Progesterone as the Major Determinants of Breast Cancer Risk: Prospects for Control by 'Natural' and 'Technological' Means	209
	Synthetic Estrogens and Liver Cancer: Risk Analysis of Animal and Human Data	217
	Carcinogenic Risk Assessment of Steroid Hormone Exposure in Relation to Prostate Cancer Risk	225
	Hormonal Carcinogenesis - Future Perspectives	237
	Cytogenetic Changes in Renal Neoplasms and During Estrogen-Induced Renal Tumorigenesis in Hamsters	247
	Pituitary Regulation of Sex-Differentiated Promotion of Rat Liver Carcinogenesis	251
	Modulation of Estrogen Metabolism by Inducers of P-4501A2: Possible Application to the Chemoprevention of Breast Cancer	254
	Estrogen Metabolism in Subcellular Preparations and Tissue Culture of Syrian Hamster Liver and Kidney	259
	Hormonal Regulation of Plasminogen Activation in the Human Endometrium	263
	Your Research - Our Lives	268
	Prostaglandin H Synthase Peroxidase Catalyzed Metabolism of Estrogens in Syrian Hamster and Rabbit Kidney	272
	Peroxidative Metabolism of Diethylestilbestrol in Ram Seminal Vesicle Cell Cultures: An In-Vitro Model for Studies of Estrogen-Induced Genotoxicity	274
	In Vivo Effects of Progesterone on Human Breast 17[beta]-Dehydrogenase and Epithelial Cells Mitotic Activities	277
	DNA Adduct Profiles in Hamster Kidney Following Chronic Exposure to Various Carcinogenic and Noncarcinogenic Estrogens	280
	Hormone-Dependent Activation of c-Ki-ras in N-Methyl-N-Nitrosourea (MNU)-Induced Mouse Mammary Tumors	285
	Growth Hormone Regulation of the c-myc Gene During Sex-Differentiated Rat Liver Carcinogenesis	288
	Fetal Stromal Cells Produce a TGF that Elicits Hyperplasia in Adult Mammary Epithelium	292
	Induction of Catechol Estrogen Formation by Indole-3-Carbinol	296
	Cytochrome P-450 Mediated Activation and Irreversible Binding of Tamoxifen to Rat and Human Liver Proteins	300
	Neonatal Diethylstilbestrol Prevents Spontaneously Developing Mammary Tumors	305
	Hormone-Dependent Uterine Adenocarcinoma Following Developmental Treatment with Diethylstilbestrol: A Murine Model for Hormonal Carcinogenesis	309
	Effects of Steroidal and Stilbene Estrogens and Their Peroxidative Metabolites on Microtubular Proteins	313
	Properties of Micronuclei Induced by Various Estrogens in Two Different Mammalian Cell Systems	318
	High-Performance Liquid Chromatography Method for the Separation of Potential Metabolites of Estradiol	323
	Ovarian Hormones Enhance the Carcinogenic Activity of 2,3,7,8-TCDD in Rats	326
	Index	331