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Preface | 1 | |
Overview | 10 | |
A. | Aspartame | 11 |
B. | The Alleged Safety of Aspartame | 11 |
C. | Aspartame Consumption | 15 |
D. | Advertisement of Aspartame Products | 21 |
E. | The Economic Impact | 24 |
F. | Evolving Doubts: "Going Public" | 27 |
G. | Corroboration | 33 |
H. | The Need for Perspective and Action | 35 |
Section 1 | Aspartame Reactors | 37 |
Chapter I. | Patient and Consumer Experiences | 39 |
Chapter II. | Clinical Data on 1,200 Aspartame Reactors | 66 |
A. | General Data and Statistics | 67 |
B. | Age Range | 74 |
C. | Aspartame Consumption | 75 |
D. | Reactions to Small Quantities | 79 |
E. | Aspartame Gum | 81 |
F. | Latent Period | 86 |
G. | Persistence of Symptoms | 88 |
H. | Gender | 88 |
I. | Seasonally Increased Consumption | 91 |
J. | Familial Ramifications | 93 |
K. | Multiple Reactions to Aspartame Products | 102 |
Section 2 | Analysis of Aspartame Reactions | 105 |
Chapter III. | Convulsions (Epilepsy) | 110 |
Chapter IV. | Eye Problems | 154 |
Chapter V. | Headache | 193 |
Chapter VI. | Other Neurologic Complications | 205 |
A. | General Considerations | 206 |
B. | Dizziness and Unsteadiness | 214 |
C. | Confusion and Memory Loss | 217 |
D. | Suspected Multiple Sclerosis | 231 |
E. | Atypical Peripheral Neuropathy | 236 |
F. | Severe Muscle Weakness; Suspect Motor Neurone Disease | 241 |
G. | Attention-Deficit/Hyperactivity; "Restless Legs"; Tourette Syndrome | 245 |
H. | Atypical and Unexplained Pain | 250 |
I. | Slurring of Speech | 253 |
J. | Tremors | 255 |
K. | Narcolepsy: Sleep Apnea | 262 |
L. | Intellectual Deterioration | 267 |
M. | Myasthenia Gravis | 276 |
N. | Pseudotumor Cerebri | 278 |
O. | Unexplained "Blackouts" | 281 |
P. | Difficulty in Expression; Dyslexia | 282 |
Chapter VII. | Psychological, Psychiatric and Behavioral Problems | 284 |
A. | General Comments and Caveats | 285 |
B. | Depression | 293 |
C. | "Anxiety Attacks" and Phobias | 302 |
D. | "Personality Changes"; Abnormal Behavior | 307 |
E. | Severe Fatigue | 312 |
F. | Insomnia | 315 |
G. | Aspartame Addiction | 318 |
Chapter VIII. | Allergies and Skin Reactions; Immunologic Perspectives | 330 |
A. | General Considerations | 331 |
B. | Itching and Hives | 337 |
C. | Other Aspartame-Associated Allergies | 347 |
D. | Photosensitivity | 351 |
E. | The Lupus Erythematosus Issue | 352 |
F. | Additional Skin Problems | 354 |
G. | Dual Sensitivity to Aspartame and Monosodium Glutamate | 358 |
H. | The Multiple Chemical Sensitivity Syndrome | 361 |
I. | Broader Immunologic Perspectives | 364 |
Chapter IX. | Additional Aspartame-Related Medical Disorders | 371 |
A. | Ear Problems | 371 |
B. | Eating Disorders | 375 |
Excessive Weight Loss | 376 | |
Anorexia Nervosa; Bulimia | 385 | |
Obesity; Paradoxic Weight Gain | 389 | |
C. | Heart and Chest Problems | 395 |
Abnormal Heart Rhythms | 395 | |
Atypical Chest Pain | 398 | |
Hypertension | 400 | |
Severe Vasomotor Reactions | 403 | |
Shortness of Breath | 404 | |
D. | Gastrointestinal Reactions | 406 |
E. | Endocrine and Metabolic Disorders | 422 |
Menstrual and Other Endocrine Changes | 423 | |
Decreased Sexuality; Infertility | 428 | |
Hypothyroidism; Thyroiditis | 429 | |
Hyperthyroidism; Pseudohyperthyroidism | 431 | |
Breast Tenderness | 436 | |
Hyperparathyroidism | 437 | |
F. | Fluid Disturbances | 438 |
Intense Thirst and Dry Mouth | 438 | |
Fluid Retention; "Bloat" | 440 | |
Urinary Complaints | 442 | |
G. | Joint/Muscle Complaints; Fibromyalgia; Muscle Cramps | 446 |
H. | Increased Susceptibility to Infection | 463 |
I. | Interference With Drug Action | 468 |
J. | Blood and Lymph Node Disorders; Altered Folic Acid Metabolism | 475 |
K. | Liver Dysfunction | 479 |
Section 3 | High-Risk Groups | 484 |
General Considerations | 485 | |
Chapter X. | Pregnant and Nursing Women | 487 |
Chapter XI. | Infants and Children | 498 |
Chapter XII. | Prior Alcoholism; Alcohol Use | 517 |
Chapter XIII. | Diabetes Mellitus | 524 |
Chapter XIV. | Hypoglycemia | 548 |
Chapter XV. | Older Persons; The Acceleration of Alzheimer's Disease | 559 |
Chapter XVI. | Families of Aspartame Reactors | 583 |
Chapter XVII. | Phenylketonuria and PKU Carriers | 587 |
Section 4 | The Questionnaire Survey for Aspartame Disease | 598 |
Chapter XVIII. | The Questionnaire | 599 |
Chapter XIX. | Responses to the Questionnaire | 608 |
Section 5 | Aspartame: Chemical Structure; Metabolism; Biophysiologic Considerations | 653 |
Chapter XX. | Metabolism; Effects of Heat and Storage; The "Normal-Protein-Building-Blocks" Fallacy | 656 |
Chapter XXI. | Methyl Alcohol (Methanol) Toxicity | 668 |
Chapter XXII. | Phenylalanine; Aspartic Acid; Stereoisomers; Amino Acid Imbalances | 686 |
Chapter XXIII | Altered Neurotransmitter Function (Including Serotonin and Cholecystokinin) | 711 |
Chapter XXIV. | Effects on Hormones and Metabolism | 721 |
Chapter XXV. | Other Hazardous Metabolites | 730 |
Section 6 | The Imminent Public Health Threat Issue | 734 |
A. | Implications of Aspartame Consumption: An Overview | 737 |
B. | The Concept of Food Additive Safety | 742 |
C. | The Imminent Hazard Regulation | 744 |
D. | Broader Public Health Perspectives | 750 |
E. | Related Considerations | 759 |
Chapter XXVI. | Epidemiology | 762 |
Chapter XXVII. | Safety Considerations | 767 |
A. | Aspartame as a "Drug" | 771 |
B. | Inadequate Labeling | 772 |
C. | The Acceptable Daily Intake (ADI) Issue | 778 |
D. | Other Potential Public Health Hazards | 784 |
E. | Tumors and Cancer; The Delaney Amendment | 795 |
F. | Brain Tumors | 800 |
G. | Occupational Exposure | 810 |
H. | The Silicone Breast Implant Litigation Issue | 812 |
I. | The "Gulf War Syndrome" | 817 |
J. | Other Indicated Areas for Research | 819 |
K. | The Issues of Saccharin and Cyclamate Safety | 826 |
Section 7 | Obstacles to Information, Education and Regulation | 832 |
A. | Historical Misgivings About Aspartame | 834 |
B. | Bureaucratic - Political - Corporate Complexities | 843 |
C. | A Reluctant Press | 845 |
D. | Related Considerations | 847 |
Chapter XXVIII. | Confused Health Care Professionals; Flawed Research | 853 |
Chapter XXIX. | The Plight of Confused Consumers | 887 |
Chapter XXX | Anti-Aspartame Consumer Advocates | 907 |
Chapter XXXI. | More Legal, Corporate and Bureaucratic Obstacles | 936 |
Chapter XXXII. | The Food and Drug Administration (FDA) | 950 |
Section 8 | Advice for Physicians and Consumers | 961 |
Chapter XXXIII. | Pointers for Physicians | 962 |
Chapter XXXIV. | Consumer Precautions and Options; "Detoxification" | 966 |
Appendices | ||
A. | Statement by H. J. Roberts, M D. for U.S. Senate Hearing, November 3, 1987 | 978 |
B. | Professional Opinion Concerning the Use of Products Containing Aspartame by Persons With Diabetes and Hypoglycemia | 980 |
C. | Professional Opinion Concerning the Use of Products Containing Aspartame by Pregnant Women, Infants and Children | 983 |
D. | Professional Opinion Concerning the Use of Products Containing Aspartame by Persons With Ear and Equilibrium Problems | 985 |
E. | Professional Opinion Concerning the Use of Products Containing Aspartame by Persons With Eye Problems | 987 |
F. | Professional Opinion Concerning Aspartame Disease Simulating Multiple Sclerosis | 989 |
G. | Professional Opinion Concerning Cardiac and Chest Complaints Attributable to Aspartame Products | 990 |
H. | Professional Opinion Concerning Allergic Reactions to Products Containing Aspartame | 992 |
I. | Professional Opinion Concerning Saccharin and Aspartame Labeling | 993 |
Bibliography | 994 | |
Index | 1019 |
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