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Preface | ||
Acknowledgments | ||
Contributors | ||
Sect. 1 | Coagulation and Fibrinolysis | |
1 | Coagulation Cascade: An Overview | 1 |
2 | Molecular Genetics of Blood Coagulation | 22 |
3 | Regulation of Coagulation | 35 |
4 | The Tissue Factor Pathway of Coagulation | 62 |
5 | Fibrin Formation and Stabilization | 81 |
6 | Regulation of Fibrinolysis | 105 |
Sect. 2 | Platelets | |
7 | Regulation of Megakaryopoiesis | 120 |
8 | Platelet Morphology and Shape Change | 140 |
9 | Platelet Membranes and Receptors | 161 |
10 | Mechanisms of Platelet Activation | 187 |
Sect. 3 | Vessel Wall | |
11 | The Endothelium in Thrombosis and Hemorrhage | 206 |
12 | Angiogenesis and Hemostasis | 220 |
13 | Vascular Response to Injury | 236 |
14 | Von Willebrand Factor | 246 |
15 | Interactions of Coagulation and Fibrinolytic Proteins with the Vessel Wall | 266 |
16 | Endothelium-derived Vasoactive Factors | 278 |
17 | Rheology | 294 |
Sect. 4 | Clinical Approach to Bleeding and Thrombosis | |
18 | Approach to Bleeding | 315 |
19 | Approach to Thrombosis | 330 |
20 | Assessment of Peripheral Arterial and Venous Thrombosis | 343 |
21 | Laboratory Methods in Hemostasis | 363 |
Sect. 5 | Quantitative Platelet Disorders | |
22 | Thrombotic Microangiopathies: Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome | 424 |
23 | Alloimmune Thrombocytopenias | 441 |
24 | Drug-induced Thrombocytopenias | 457 |
25 | Immune Thrombocytopenic Purpura | 476 |
26 | Thrombocytosis | 496 |
Sect. 6 | Qualitative Platelet Disorders | |
27 | Congenital Disorders of Platelet Function | 507 |
28 | Acquired Disorders of Platelet Function | 525 |
Sect. 7 | Disorders of Coagulation Factors and Fibrinolysis | |
29 | Von Willebrand Disease | 539 |
30 | Hemophilia - Factor VIII Deficiency | 560 |
31 | Other Coagulation Factor Deficiencies | 575 |
32 | Factor VIII and Other Coagulation Factor Inhibitors | 599 |
33 | Antiphospholipid Syndrome and Lupus Anticoagulants | 611 |
Sect. 8 | Thrombotic Disorders | |
34 | The Relationship Between Thrombosis and Atherosclerosis | 628 |
35 | Inherited and Acquired Hypercoagulable States | 648 |
36 | Clinical Manifestations of Endothelial Dysfunction | 685 |
Sect. 9 | Other Disorders of Hemostasis | |
37 | Less Common Thrombotic and Embolic Disorders | 707 |
38 | Vascular Purpura and Diseases of Blood Vessels | 763 |
39 | Disseminated Intravascular Coagulation | 781 |
40 | Coagulopathy of Liver Failure and Vitamin K Deficiency | 803 |
41 | Maternal Hemostasis: Coagulation Problems of Pregnancy | 816 |
42 | Hemorrhage, Thrombosis, and Antithrombotic Therapy in Children | 840 |
43 | Interaction of Blood and Artificial Surfaces | 865 |
Sect. 10 | Management of Bleeding | |
44 | Platelet Transfusion Therapy | 886 |
45 | Plasma and Component Therapy | 897 |
46 | Nontransfusional Hemostatic Agents | 915 |
Sect. 11 | Management of Thrombosis | |
47 | Pharmacology of Antiplatelet Agents | 929 |
48 | Pharmacology of Heparin-related Compounds and Coumarin Derivations | 939 |
49 | The Pharmacology of Thrombolytic Agents | 949 |
50 | New Antithrombotic Strategies | 978 |
51 | Bleeding Complications of Antithrombotic Therapy | 996 |
52 | Antithrombotic Interventions in Cerebrovascular Disease | 1003 |
53 | Antithrombotic Therapy in Ischemic Heart Disease | 1030 |
54 | Antithrombotic Therapy in Peripheral Vascular Disease | 1053 |
55 | Anticoagulants in Atrial Fibrillation | 1066 |
56 | Prevention and Treatment of Venous Thromboembolic Disease | 1077 |
57 | Gene Therapy of Thrombotic and Hemorrhagic Disorders | 1096 |
Index | 1109 |
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