In 2008, she was appointed a Goodwill Ambassador for Integrity by the United Nations. She made her directorial debut with Bringing Up Bobby in 2011. She is also known for her role in the Netflix original series Hemlock Grove and for her role in ABC's How to Get Away with Murder. Janssen starred in the 2017 NBC crime thriller The Blacklist: Redemption.
In addition to her native Dutch, Janssen speaks English and French. She learned German, but has not kept up with it.
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