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Foreword | ||
The Concerted Action EUROBIOMAT -Hemocompatibility- | ||
Introduction | ||
General Information and Instructions | ||
Pt. I | Physical, Chemical and Physico-chemical Methods for Surface and Bulk Characterisation | |
Surface Characterization of EUROBIOMAT Reference Polymers | 3 | |
Surface Analysis of Polymer Biomaterials by Electron Spectroscopy for Chemical Analysis (ESCA) | 17 | |
Surface Infrared Analysis of Standard Biomaterials | 27 | |
Contact Angles on Polymer Reference Materials | 37 | |
Zeta-Potentials and Surface Tensions | 49 | |
The Surface Energy Spectra of Polymers | 65 | |
Supercritical Fluid Extraction / Chromatography (SFE/C) of Additives from Standard Biomaterials for Use in Biocompatibility Testing | 75 | |
Determination of Surface Energetic Properties by Contact Angle Measurements | 85 | |
Advancing and Receding Water Contact Angle Measurements with Drops, Bubbles and Plates | 95 | |
Screening Test for Residual Ethylene Oxide on Reference Materials | 107 | |
The Average Molecular Weight of the Reference Materials | 113 | |
Pt. II | Biological, Biochemical, Immunological, Hematological and Toxicological Methods to Evaluate the Biocompatibility of the Reference Materials | |
Activation of the Human Complement System by "Standard" Polymers | 121 | |
Photometric Enzyme Immunoassay for the Quantitative Determination of C3a-des Arg in Human Plasma Incubated with Polymeric Biomaterials | 127 | |
Complement Activation, Cytotoxicity and Leaching of Substances | 139 | |
Enzyme-Linked Immunosorbent Assays for Biocompatibility Testing | 147 | |
Measurement of Platelet Adhesion, released [beta]-Thromboglobulin and Generated Fibrinopeptide A Using whole Non-anti-coagulated Blood at Flow Conditions | 157 | |
Perfusion Technique for in vitro Evaluation of Platelet Interaction with Biomaterials in Catheter Form | 165 | |
In-vitro Hemocompatibility Screening Test by Using the Resonance-Thrombography | 173 | |
The Hemocompatibility of Reference Materials in-vitro; Comparative Investigation of Platelet Adhesion/Activation and Platelet Aggregability | 183 | |
Cell Culture Cytotoxicity Assays as Part of the Biocompatibility Testing of Standard Biomaterials | 193 | |
Quantitative Evaluation of Cytotoxicity in vitro of Extracts from Standard Biomaterials | 201 | |
In-vitro Toxicity of the Reference Materials. The Ciliata-Test | 211 | |
Keratinocyte Cell Cultures for Testing Polymers for Percutaneous Devices | 217 | |
Blood-Testing of a Polyether-Urethane as a Diffusion Limiting and Potentially Haemocompatible External Membrane for Enzyme Electrode Biosensors | 227 | |
Biocompatibility Evaluation of Reference Materials | 237 |
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