Tumor Targeting in Cancer Therapy Book

Part I. A Review

The Current Status of Tumor Targeting: A Review

Tarunendu Ghose

Clinical Applications of Targeted Therapeutics

Tarunendu Ghose

Part II. Targeting Tumors with Drug Antibody Conjugates

Targeting the CD22 Receptor with RNA Damaging Agents

Huaitian Liu, Dianne L. Newton, Hans J. Hansen, Stanislaw M. Mikulski, David M. Goldenberg, Edward A. Sausville, and Susanna M. Rybak

The Development of Liposomes for Enhanced Delivery of Chemotherapeutics to Tumors

Paul Tardi, Ludger Ickenstein, Marcel Bally, and Lawrence Mayer

Overcoming Multiple Drug Resistance with Anti-Pgp Carrier

Brigitte Pagé and Michel Pagé

Targeting with Transferrin, Mandip Singh

Synthesis and Evaluation of Paclitaxel Immunoconjugate with Antitumor Activity In Vitro

Jairo Jaime Correa and Michel Pagé

The Use of Drug-Monoclonal Antibody Conjugates for the Treatment of Cancer

Geoffrey A. Pietersz and Ian F. C. McKenzie

Part III. Targeting Tumors with Antibodies

Targeting Vascular Endothelium with Antibodies

Przemek Twardowski and Kim Margolin

Targeting B-Cell Non-Hodgkin's Lymphoma with Monoclonal Antibodies

Christian Buske and W. Hiddemann

From Bench to Bedside: Development of Rituximab (Rituxan ®), A Monoclonal Antibody for the Therapy of Non-Hodgkin's Lymphoma

Roland Newman

Mylotarg: The First Antibody-Targeted Chemotherapy Agent

Philip R. Hamann and Mark S. Berger

Part IV. Targeting Tumors with Radioimmunoconjugates

188Rhenium-Labeled Trisuccin-DCh2HuCC49 as a Radioimmunotherapy Model in Nude Mice

Ahmad Safavy and Donald J. Buchsbaum

Part V. Targeting Tumors with Immunotoxins

General Approach for Targeting Toxins

Manish Monga, Richard A. Messman, and Edward A. Sausville

Antibody-Toxin Conjugates: Chemistry of Coupling and Purification

Silvana Canevari, Maria Ines Colnaghi, Luigi Cattel, and Franco Dosio

Shiga-Like Toxins as Targeted Anticancer Agents

Paul LaPointe and Jean Gariépy

Part VI. Targeting Tumors with Antibody-Enzyme Conjugates (ADEPT)

Antibody-Directed Enzyme Prodrug Therapy with Carboxypeptidase G2: Clinical Studies

Kenneth D. Bagshawe

Part VII. Photodynamic Therapy

Photodynamic Therapy: Targeting Cancer Cells with Photosensitizer-Bioconjugates

Cynthia M. Allen, Wesley M. Sharman, and Johan E. van Lier

Tumor Targeting Using PEG-m-THPC for Photodynamic Therapy in a Rat Ovarian-Cancer Model

René Hornung

Part VIII. Targeting Tumors with Magnetic Drugs

Targeting Tumors with Magnetic Drugs

Andreas S. Lübbe, Christian Bergemann, and Christoph Alexiou

Part IX. Principles and Techniques in Targeting

Internalization of Antibodies

Jairo Jaime Correa

Bioconjugation and Biodistribution

Francesco M. Veronese and Paulo Caliceti

Principles of Antitumor Targeting of Cytotoxic Drugs

Gene M. Dubowchik

Targeting by Antibody or Ligand: Which Is Better?

Douglas A. Lapp

Index