Toxicology and Risk Assessment: A Comprehensive Introduction Book

Preface.

List of Contributors.

1 Introduction to the Discipline of Toxicology (Helmut Greim and Robert Snyder).

1.1 Introduction.

1.2 The Risk-Assessment Process.

1.3 Toxicological Evaluation of New and Existing Chemicals.

1.4 Summary.

2 Principles.

2.1 Toxicokinetics (Johannes G. Filser).

2.2A Phase I Metabolism (Jeroen T.M. Buters).

2.2B Drug Metabolism (Leslie Schwarz and John B. Watkins).

2.3 Toxicogenetics (Lesley Stanley).

2.4 Cytotoxicity (Leslie Schwarz and John B. Watkins).

2.5 Receptor-Mediated Mechanisms (Jens Schlossmann and Franz Hofmann).

2.6 Mixtures and Combinations of Chemicals (Victor J. Feron and Diana Jonker).

2.7 Chemical Carcinogenesis: Genotoxic and Nongenotoxic Mechanisms (Thomas Efferth and Bernd Kaina).

2.8 Reproductive Toxicology (Horst Spielmann).

2.9 Ecotoxicology: Not just Wildlife Toxicology (Peter Calow and Valery E. Forbes).

3 Organ Toxicology.

3.1 The Gastrointestinal Tract (Michael Schwenk).

3.2 The Liver (Leslie Schwarz and John B. Watkins).

3.3 The Respiratory System (Jurgen Pauluhn).

3.4 The Nervous System (Gunter P. Eckert and Walter E. Mu¨ller).

3.5 Behavioral Neurotoxicology (Andreas Seeber).

3.6 The Skin (Tibor A. Rozman, Myriam Straube and Karl K. Rozman).

3.7 The Kidney and Urinary Tract (Helmut Greim).

3.8 Toxicology of the Blood and Bone Marrow (Robert Snyder).

3.9 Immunotoxicology (Carol R. Gardner and Debra L. Laskin).

3.10 The Eye (Ines M. Lanzl).

3.11 The Cardiovascular System (Helmut Greim).

4 Methods in Toxicology.

4.1 OECD Test Guidelines for Toxicity Tests in vivo (Rudiger Bartsch).

4.2A Mutagenicity Tests in vivo (Ilse-Dore Adler).

4.2B In vitro Tests for Genotoxicity (Ulrich Andrae and Gunter Speit).

4.2.C Strategies for the Evaluation of Genotoxicity (Stephan Madle, Peter Kasper, Ulrike Pabel and Gunter Speit).

4.3 Biomonitoring (Michael G. Bird).

4.4 Epidemiology (Kurt Ulm).

4.5 Omics in Toxicology (Laura Suter-Dick and Thomas Singer).

4.6 Introduction to the Statistical Analysis of Experimental Data (Gyorgy Csanady).

5 Risk Assessment.

5.1 Mathematical Models for Risk Extrapolation (Jurgen Timm).

5.2 Regulations Regarding Chemicals and Radionuclides in the Environment, Workplace, Consumer Products, Foods, and Pharmaceuticals (Dennis J. Paustenbach and Pearl Moy).

6 Toxicity of Selected Chemicals.

6.1 Persistent Polyhalogenated Aromatic Hydrocarbons (Kristian W. Fried and Karl K. Rozman).

6.2 Metals (Karl-Heinz Summer, Stefan Halbach, Herrmann Kappus and Helmut Greim).

6.3 Toxicology of Fibers and Particles (Paul J.A. Borm).

6.4 Xenoestrogens and Xenoantiandrogens (Gisela H. Degen and J. William Owens).

6.5 Toxicology of Solvents (Wolfgang Dekant and Marion W. Anders).

6.6 Noxious Gases (Ladislaus Szinicz).

6.7 Animal and Plant Toxins (Thomas Zilker).

Index.