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The Skeleton Book

The Skeleton
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The Skeleton, Because the skeleton is a complex multifunctional system that significantly affects immunity, circulation, intracellular signaling, and the endocrine system, it is of great interest to researchers and clinicians in a broad range of biomedical disciplines., The Skeleton
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  • The Skeleton
  • Written by author Massaro, Edward J., Rogers, John M
  • Published by Springer-Verlag New York, LLC, 11/5/2010
  • Because the skeleton is a complex multifunctional system that significantly affects immunity, circulation, intracellular signaling, and the endocrine system, it is of great interest to researchers and clinicians in a broad range of biomedical disciplines.
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Authors

Preface
Contributors
1 Molecular Basis of Cell-Cell Interaction and Signaling in Mesenchymal Chondrogenesis 3
2 Chondrocyte Cell Fate Determination in Response to Bone Morphogenetic Protein Signaling 17
3 Regulation of Chondrocyte Differentiation 43
4 Continuous Expression of Cbfal in Nonhypertrophic Chondrocytes Uncovers Its Ability to Induce Hypertrophic Chondrocyte Differentiation and Partially Rescues Cbfal-Deficient Mice 55
5 Molecular Biology and Biosynthesis of Collagens 77
6 Mechanotransduction Pathways in Cartilage 89
7 Molecular Genetic Analysis of the Role of the HoxD Complex in Skeletal Development: Impact of the loxP/Cre System in Targeted Mutagenesis of the Mouse HoxD Complex 101
8 Control of Development and Homeostasis Via Regulation of BMP, Wnt, and Hedgehog Signaling 113
9 FGF4 and Skeletal Morphogenesis 131
10 Retinoid Signaling and Skeletal Development 147
11 Retinoids and Indian Hedgehog Orchestrate Long Bone Development 159
12 Synergy Between Osteogenic Protein-1 and Osteotropic Factors in the Stimulation of Rat Osteoblastic Cell Differentiation 173
13 Bone Morphogenic Proteins, Osteoblast Differentiation, and Cell Survival During Osteogenesis 185
14 Osteoclast Differentiation 195
15 Soluble Signals and Insoluble Substrata: Novel Molecular Cues Instructing the Induction of Bone 217
16 Perichondrial and Periosteal Regulation of Endochondral Growth 229
17 Computer Simulations of Cancellous Bone Remodeling 249
18 Effects of Microgravity on Skeletal Remodeling and Bone Cells 263
19 Quantitative Analyses of the Development of Different Hard Tissues 279
20 Fetal Mineral Homeostasis and Skeletal Mineralization 293
21 Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D 307
22 Role of Pax3 and PDGF-[alpha] Receptor in Skeletal Morphogenesis and Facial Clefting 335
23 Genetics of Achondroplasia and Hypochondroplasia 349
24 Effects of Boric Acid on Hox Gene Expression and the Axial Skeleton in the Developing Rat 361
25 Toxicant-Induced Lumbar and Cervical Ribs in Rodents 373
26 Experimental Skeletal Dysmorphology: Risk Assessment Issues 385
Index 415


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