Targeted Interference with Signal Transduction Events Book

Identifying critical signaling molecules for the treatment of cancer. Tyrosine kinase inhibitors and cancer therapy. Targeting ERBB receptors in cancer. Inhibition of the IGF-I receptor for treatment of cancer: kinase inhibitors and monoclonal antibodies as alternative approaches. Inhibition of the TGF-ß signaling pathway in tumor cells. The mammalian target of rapamycin kinase (mTOR) and tumor growth inhibition. The Ras signaling pathway as a target in cancer therapy. The mitogen activated protein kinase pathway for molecular-targeted cancer treatment. The function and the inhibition of the c-SRC gene in tumor cells.