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Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches Book

Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches
Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches, Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches has a rating of 4 stars
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Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches, Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches
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  • Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches
  • Written by author Michael E. Burczynski
  • Published by Informa Healthcare, November 2005
  • Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach
  • Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach
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Ch. 1Introduction to surrogate tissue analysis3
Ch. 2Impact of sample handling and preparation on gene signatures as exemplified for transcriptome analysis of peripheral blood15
Ch. 3Blood genomic fingerprints of brain diseases31
Ch. 4Transcriptional profiling of peripheral blood in oncology47
Ch. 5Blood-derived transcriptomic profiles as a means to monitor levels of toxicant exposure and the effects of toxicants on inaccessible target tissues65
Ch. 6Spermatozoal RNAs as surrogate markers of paternal exposure77
Ch. 7Proteomic analysis of surrogate tissues : mass spectrometry-based profiling of the circulatory proteome for cancer detection and stratification93
Ch. 8Lymphocyte integrins : potential surrogate biomarkers for evaluation of endometrial receptivity109
Ch. 9Nipple aspirate fluid to diagnose breast cancer and monitor response to treatment123
Ch. 10Metabonomics : metabolic profiling and pattern recognition analysis of body fluids and tissues for characterization of drug toxicity and disease diagnosis143
Ch. 11Comprehensive metabolomic profiling of serum and cerebrospinal fluid : understanding disease, human variability, and toxicity165
Ch. 12Lipidomic analysis of plasma and tissues : lipid-derived mediators of inflammation and markers of disease185
Ch. 13Molecular detection and characterization of circulating tumor cells and micrometastases in solid tumors203
Ch. 14Methylation profiling of tumor cells and tumor DNA in blood, urine, and body fluids for cancer detection and monitoring229
Ch. 15Regulatory and technical challenges in incorporating surrogate tissue profiling strategies into clinical development programs249
Ch. 16Considerations in the economic assessment of the value of molecular profiling263
Ch. 17The impact and challenges of pan-ornic approaches in pharmaceutical discovery and development275
Ch. 18Current and future aspects of surrogate tissue analysis291


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Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches, Despite rapidly expanding interest in potential applications of surrogate tissue analysis and intense competition to identify and validate biomarkers in appropriate surrogate tissues, very few peer reviewed publications describing the use of this approach, Surrogate Tissue Analysis: Genomic, Proteomic, and Metabolomic Approaches

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