Stress-Inducible Cellular Responses Book

	Foreword
	Introduction
Pt. I	Functions of stress proteins in unstressed cells
	Introduction	2
	Normal protein folding machinery	3
	Roles for hsp70 in protein translocation across membranes of organelles	25
	Protein folding and assembly in the endoplasmic reticulum	41
	Involvement of molecular chaperones in intracellular protein breakdown	57
	Molecular chaperoning of steroid hormone receptors	79
	Protein disulfide isomerase: A multifunctional protein of the endoplasmic reticulum	97
Pt. II	Regulation of inducible stress responses
	Introduction	120
	Sensing stress and responding to stress	121
	The transcriptional regulation of heat shock genes: A plethora of heat shock factors and regulatory conditions	139
	Transcriptional regulation of stress-inducible genes in procaryotes	165
	The impact of oxidative stress on eukaryotic iron metabolism	183
	Heat-shock induced protein modifications and modulation of enzyme activities	199
	SOS response as an adaptive response to DNA damage in prokaryotes	221
Pt. III	Cellular responses to specific stresses
	Introduction	238
	Transcriptional regulators of oxidative stress-inducible genes in prokaryotes and eukaryotes	239
	UV activation of mammalian stress proteins	255
	Signaling events controlling the molecular response to genotoxic stress	273
	Mammalian DNA repair responses and genomic instability	289
	Toxic metal-responsive gene transcription	307
	Tumor necrosis factor and lymphotoxin: Protection against oxidative stress through induction of MnSOD	321
Pt. IV	Paradigms for complex stress responses
	Introduction	336
	Viral infection	337
	Infection, autoimmunity and autoimmune disease	359
	Stress proteins in inflammation	375
	Attenuated heat shock transcriptional response in aging: Molecular mechanism and implication in the biology of aging	393
Pt. V	Applications of stress responses in toxicology and pharmacology
	Introduction	410
	Stress proteins as molecular biomarkers for environmental toxicology	411
	Thermotolerance and heat shock proteins: Possible involvement of Ku autoantigen in regulating HSP70 expression	425
	Heat shock proteins as immunological carriers and vaccines	451
	Regulation of thermotolerance and ischemic tolerance	467
	Future applications	483
	Outlook	485
	Subject index	489