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Book Categories |
| Foreword | ||
| List of Abbreviations | ||
| 1 | Introduction, Basic Concepts and Strategies | 1 |
| 1.1 | Opening remarks (DO) | 1 |
| 1.2 | Historical landmarks in solid-supported organic synthesis (DO) | 5 |
| 1.3 | Applications of solid-supported organic chemistry (DO) | 10 |
| 1.4 | The role of solid-supported chemistry in modern drug discovery (DO) | 17 |
| 1.5 | Solid supports (PE) | 24 |
| 1.6 | Solid-supported reagents (PE) | 44 |
| 1.7 | Linker molecules and cleavage strategies (BD, DO) | 85 |
| 1.8 | Synthetic strategies in combinatorial and parallel synthesis (DO, TM) | 105 |
| 1.9 | Classification of reactive building blocks (DO) | 127 |
| 1.10 | Tagging and deconvolution (KS) | 145 |
| 1.11 | Diversity (planning/assessment) (PJ) | 156 |
| 1.12 | Analytical methods (PJ) | 158 |
| 1.13 | Robotic systems and workstations (DO) | 160 |
| 2 | Linear Assembly Strategies | 185 |
| 2.1 | Introduction | 185 |
| 2.2 | Peptides | 186 |
| 2.3 | Conformationally constrained peptides | 188 |
| 2.4 | Peptoids | 197 |
| 2.5 | Oligonucleotides | 200 |
| 2.6 | Oligosaccharides | 201 |
| 2.7 | Oligocarbamates and oligoureas | 205 |
| 2.8 | Peptide-Nucleic acids (PNA) | 207 |
| 3 | Library Synthesis in Solution Using Liquid-Liquid and Liquid-Solid Extractions and Polymer-Bound Reagents (CZ, TM, DO) | 213 |
| 3.1 | General | 213 |
| 3.2 | Applications of solution-phase multicomponent and multigeneration reactions | 217 |
| 3.3 | Applications of liquid-liquid phase extractions | 222 |
| 3.4 | Applications of liquid-solid phase extractions and polymer-bound scavengers | 224 |
| 3.5 | Applications of polymer-bound reagents | 228 |
| 3.6 | Applications of polymer-bound catalysts | 235 |
| 3.7 | Solution chemistry using temporary trapping of intermediates on solid support ("intermediate catch" or "resin capture") | 246 |
| 3.8 | Organic synthesis on soluble polymeric supports | 252 |
| 4 | Convergent Assembly Strategies on Solid Supports (JMV) | 259 |
| 4.1 | Multigeneration assembly strategies with single functional group liberation | 259 |
| 4.2 | Multigeneration assembly strategies using traceless linkers | 292 |
| 4.3 | Multicomponent assembly strategies with single functional group liberation | 300 |
| 4.4 | Multigeneration assembly strategies with cyclisation-assisted cleavage | 306 |
| 4.5 | Multicomponent assembly strategy with cyclisation-assisted cleavage | 318 |
| 4.6 | Multigeneration assembly strategies with multidirectional cleavage | 319 |
| Outlook and future directions | 334 | |
| Subject Index | 335 | |
| Acknowledgements | 339 |
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Kyongon Choi
reviewed Solid Supported Combinatorial & Parallel Synthesis Of Smallmolecular Weight Compound Librariestetrahedron Organic Chemistry Series Volume 17 on June 16, 2014
Solid Supported Combinatorial And Parallel Synthesis Of Smallmolecular Weight Compound Librariestetrahedron Organic Chemistry Series Volume 17
I was asked to review this book for Nature. I accepted the assignment because it is a book about fragile X syndrome and I have a project about this condition.
I was completely blown away - this is a phenomenal book - among the best I have ever read. Clare Dunsford is a masterful writer, but more than that - she is a truth-teller, a truth-seeker, and a revolutionary. Her ability to guide the reader through the experiences associated with having a child with fragile X is so exquisite, that even those with children with different conditions (I have two kids with pseudoxanthoma elasticum (PXE) ), will find their own story told.
I have written my review, which is suppose to appear in the July issue of Nature. I have also decided, with my colleagues, to award Clare Dunsford the Genetic Alliance Art of Advocacy Award in July, at the Genetic Alliance Annual Conference (www.geneticalliance.org).
Wow.
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Add Solid Supported Combinatorial & Parallel Synthesis Of Smallmolecular Weight Compound Librariestetrahedron Organic Chemistry Series Volume 17, The words Combinatorial Chemistry have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, , Solid Supported Combinatorial And Parallel Synthesis Of Smallmolecular Weight Compound Librariestetrahedron Organic Chemistry Series Volume 17 to the inventory that you are selling on WonderClubX
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Add Solid Supported Combinatorial & Parallel Synthesis Of Smallmolecular Weight Compound Librariestetrahedron Organic Chemistry Series Volume 17, The words Combinatorial Chemistry have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, , Solid Supported Combinatorial And Parallel Synthesis Of Smallmolecular Weight Compound Librariestetrahedron Organic Chemistry Series Volume 17 to your collection on WonderClub |
