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Series Introduction iii
Preface v
Contributors ix
Background
Historical Milestones in Reperfusion Therapy for Myocardial Infarction Eugene Braunwald 1
Pathophysiology of Myocardial Infarction Sameer Amin Prediman K. Shah 15
Successful Myocardial Reperfusion Claudia P. Hochberg C. Michael Gibson 29
Fibrinolytic Reperfusion
Infusion Fibrinolytic Therapy Eric R. Bates 43
Bolus Fibrinolytic Therapy Peter R. Sinnaeve Frans J. Van de Werf 59
Treatment Opportunities with Fibrinolytic Therapy Robert C. Welsh Paul W. Armstrong 71
Catheter-based Reperfusion
Primary Percutaneous Coronary Intervention Nestor Mercado Simon R. Dixon William W. O'Neill 91
Rescue PCI Damian J. Kelly Anthony H. Gershlick 119
Facilitated Percutaneous Coronary Intervention in Acute Myocardial Infarction E. Magnus Ohman Mauricio G. Cohen 137
Primary PCI with Off-Site Cardiac Surgery Backup Thomas P. Wharton 155
Interhospital Transfer for Primary PCI Brahmajee K. Nallamothu 167
Adjunctive Therapy
Antiplatelet Agents Farzin Beygui Gilles Montalescot 177
Anticoagulant Agents E. Marc Jolicoeur Christopher B. Granger 195
Myocyte Protection by Pharmacological Therapy David Faxon 233
Myocyte Protection by Device Therapy Sanjeevan Pasupati John G. Webb 249
Challenges and Opportunities
Optimal Strategies for Prehospital and Emergency Department Evaluation of Patients with STEMI Judd E. Hollander 265
Management of Complications Steven M. Hollenberg 281
Myocyte Regeneration Eduardo I. de Oliveira Stephen G. Ellis 301
The Future of Reperfusion Therapy Elliott M. Antman 317
Appendix
Recommendations from the ACC/AHA Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction 333
ESC STEMI Guidelines 377
Index 379
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