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Preface | ||
Contributors | ||
Introduction | ||
Pt. 1 | Rationale | |
1 | The Rationale for rDNA Vaccines | 1 |
2 | Modern Approaches to the Development of Attenuated Virus Strains | 19 |
3 | Development of Nontoxic Immunogenic Analogs of Toxins for Vaccines with Emphasis on Pertussis Toxin | 49 |
4 | Bacterial Virulence as Strategies to Develop Vaccines | 73 |
5 | Phase and Antigenic Variation of Bacterial Colonization Factors in the Development of Recombinant Vaccines | 89 |
6 | Antigenic Variation in Parasitic Protozoa | 115 |
7 | Strategies to Achieve Mucosal Immunity | 147 |
Pt. 2 | Strategy | |
8 | Cloning Strategies in Prokaryotes | 169 |
9 | The Utility of Fusion Proteins in the Development of Vaccines | 199 |
10 | Vaccinia Virus as a Cloning and Delivery System for Vaccines | 223 |
11 | Baculovirus Expression Vectors | 265 |
12 | Use of Attenuated Bacteria as Live Oral Vaccine Vectors | 293 |
13 | Minicells as Specialized Vaccines and Vaccine Carriers | 323 |
14 | Rationale for the Design of Anti-Idiotypic Antibody Vaccines | 335 |
15 | The Iscom--An Approach to Subunit Vaccines | 369 |
16 | Safety of Recombinant Vaccines | 387 |
Index | 401 |
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