Progress in Iron Research Book

1	Mechanism of Fe(II) Oxidation and Core Formation in Ferritin	1
2	Chemico-Physical and Functional Differences Between H and L Chains of Human Ferritin
3	Iron Oxidation in Sheep, Horse and Recombinant Human Apoferritins	23
4	The Transferrin Receptor and the Release of Iron from Transferrin	31
5	The Roles of Secondary Binding Sites for Transferrin in the Liver and on Macrophages	41
6	Optimized Separation and Quantitation of Serum and Cerebrospinal Fluid Transferrin Subfractions Defined by Differences in Iron Saturation or Glycan Composition	51
7	Mechanism of Production of the Serum Transferrin Receptor	61
8	Iron Absorption and Cellular Uptake of Iron	69
9	Ferric Iron Reduction and Iron Uptake in Eucaryotes: Studies with the Yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe	81
10	Cellular Responses to Iron and Iron Compounds	91
11	The Structure and Function of Iron Regulatory Factor	101
12	Structure and Function of IREs, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase	111
13	Translational Control by Iron-Responsive Elements	119
14	The Role of Cytokines in the Regulation of Ferritin Expression	127
15	Stimulation of IRE-BP Activity of IREF by Tetrahydrobiopterin and Cytokine Dependent Induction of Nitric Oxide Synthase
16	Reciprocal Modulation of Aconitase Activity and RNA-binding Activity of Iron Regulatory Factor by Nitric Oxide	141
17	A New Look at Ferritin Metabolism	149
18	Bacterioferritin: A Hemoprotein Member of the Ferritin Family	157
19	Intracellular Iron	165
20	Distinct Features of Iron Metabolism in Erythroid Cells: Implications for Heme Synthesis Regulation	173
21	Cellular Ferritin Uptake: A Highly Regulated Pathway for Iron Assimilation in Human Erythroid Precursor Cells	189
22	Differential Effects of Iron and Iron Carrier on Hematopoietic Cell Differentiation and Human ADA Gene Transfer	199
23	A Hemin-Inducible Enhancer Lies 4.5 Kb Upstream of the Mouse Ferritin H Subunit Gene	211
24	Iron Deficiency: The Global Perspective	219
25	Iron Regulation in the Brain at the Cell and Molecular Level	229
26	Pathophysiology of Iron Toxicity	239
27	Morphologic Observations in Iron Overload: An Update	255
28	Identification of Thiolic Sarcolemmal Proteins as a Primary Target of Iron Toxicity in Cultured Heart Cells	267
29	Iron Overload and the Biliary Route	277
30	Changing Concepts of Haemochromatosis	285
31	Epidemiology, Clinical Spectrum and Prognosis of Hemochromatosis	293
32	The Morbidity of Hemochromatosis Among Clinically Unselected Homozygotes: Preliminary Report	303
33	Genetics of Haemochromatosis	309
34	Localization of Seven New Genes Around the HLA-A Locus	319
35	Searching for the Hemochromatosis Grail	331
36	Iron Chelator Design	343
37	Results from a Phase I Clinical Trial of HBED	351
38	Lessons from Preclinical and Clinical Studies with 1,2-Diethyl-3-Hydroxypyridin-4-One, CP94 and Related Compounds	361
39	Iron Chelation Therapy for Malaria	371
40	The Biochemical Basis for the Selective Antimalarial Action of Iron Chelators on Plasmodium Falciparum Parasitized Cells	385
	Index	399