Portal Hypertension: Pathobiology, Evaluation, and Treatment Book

Part I. Historical Perspective

Portal Hypertension: A History

Adrian Reuben and Roberto J. Groszmann

Part II. Pathobiology and Experimental Progress in Portal Hypertension

Anatomy and Vascular Biology of the Cells in the Portal Circulation

Massimo Pinzani and Francesco Vizzutti

Cell and Molecular Mechanisms of Increased Intrahepatic Resistance and Hemodynamic Correlates

Don C. Rockey

Molecular Mechanisms of Systemic Vasodilation and Hyperdynamic Circulatory State of Cirrhosis

Richard Moreau and Didier Lebrec

Mechanisms of Sodium Retention, Ascites Formation, and Renal Dysfunction in Cirrhosis

Andr&e's Cárdenas and Pere Ginès

Hepatic Hemodynamics in Portal Hypertension: Compliance, Hepatic Arterial Buffer Response, Hepatorenal Syndrome, and Liver Regeneration

W. Wayne Lautt and Zhi Ming

Neovascularization, Angiogenesis, and Vascular Remodeling in Portal Hypertension

Manuel Morales-Ruiz and Wladimiro Jiménez

Mechanisms of Cardiopulmonary Hemodynamics and Dysfunction in Portal Hypertension

Michael B. Fallon

Part III: Methodology to Assess Portal Hypertension in Humans

Measurement of Hepatic Venous Pressure Gradient: Methods, Interpretation, and Pitfalls

G. Pomier-Layrargues and P. Michel Huet

Evaluation of Portal Hemodynamics Using Indicator Dilution and Noninvasive Techniques

Juerg Reichen

Endoscopic Assessment of Portal Hypertension Including Variceal Pressure Measurements: Methods, Interpretation, and Pitfalls

Àngels Escorsell and Jaime Bosch

Part IV: Natural History and Treatment of Esophageal Varices

Clinical Features and Natural History of Variceal Hemorrhage: Implications for Surveillance and Screening

Juan G. Abraldes and Jaime Bosch

Management Strategies for the Prophylaxis and Treatment of Esophageal Variceal Rupture: An Overview

Roberto de Franchis

Pharmacologic Therapy for the Management of Esophageal Varices: Biology and Utility of Available Agents

Norman D. Grace and Richard S. Tilson

Endoscopic Treatment for Bleeding Esophageal Varices

John P. Cello

Surgical Therapies for Management: Surgical Shunts and Liver Transplantation

J. Michael Henderson

Transjugular Intrahepatic Portosystemic Stent-Shunt: Technical Considerations and Clinical Utility in the Management of Variceal Hemorrhage

Dhiraj Tripathi, Peter C. Hayes, Doris N. Redhead, and Rajiv Jalan

Clinical Features and Management of Gastric Varices, Portal Hypertensive Gastropathy, and Ectopic Varices

Charmaine A. Stewart and Patrick S. Kamath

Part V: Natural History and Treatment of Ascites and Hepatorenal Syndrome

Ascites: Clinical Features, Diagnosis, and Natural History

Sakib Karim Khalid and Guadalupe Garcia-Tsao

Management of Ascites

Florence Wong

Spontaneous Bacterial Peritonitis and Other Infections in Cirrhosis

Rosa Maria Morillas and Ramon Planas

Diagnosis and Management of the Hepatorenal Syndrome

Kevin Moore

Part V: Evaluation and Treatment in Special Circumstances of Portal Hypertension

Pregnancy and Portal Hypertension

Bimaljit Sandhu and Arun J. Sanyal

Causes and Management of Portal Hypertension in the Pediatric Population

Frederick C. Ryckman, Maria H. Alonso, and Greg Tiao

Noncirrhotic Portal Hypertension and Portal Vein Thrombosis

Shiv K. Sarin and Manav Wadhawan

Hepatic Venous Outflow Obstruction: Budd-Chiari Syndrome and Veno-Occlusive Disease (Sinusoidal Obstruction Syndrome)

Hugo E. Vargas and Thomas D. Boyer

Pulmonary Complications Associated with Portal Hypertension

Karen L. Swanson and Michael J. Krowka

Health Status Assessment and Economic Analyses in Cirrhosis and Portal Hypertension

Jayant A. Talwalkar and W. Ray Kim

Future Treatments: Antifibrotic Agents, Nitric Oxide Donors, and Gene Therapy in the Treatment of Portal Hypertension

Meena B. Bansal and Scott L. Friedman

Index