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Contributors ix
List of abbreviations xi
1 Opioid receptors and opioid pharmacodynamics Mellar P. Davis Gavril W. Pasternak 1
2 Opioid pharmacokinetics Kenneth C. Jackson II Mellar P. Davis Columba Quigley 29
3 Liver disease and exogenous opioid pharmacokinetics Mellar P. Davis 39
4 Opioids in renal failure Janet R. Hardy 69
5 Codeine Janet R. Hardy Kenneth C. Jackson II 81
6 Hydrocodone Mellar P. Davis 89
7 Tramadol Mellar P. Davis Paul Glare 99
8 Dextropropoxyphene Paul Glare 119
9 Morphine Paul Glare 127
10 Oxycodone Paul Glare Mellar P. Davis 155
11 The lipophilic opioids: fentanyl, alfentanil, sufentanil, and remifentanil Anthony Hall Janet R. Hardy 175
12 Buprenorphine Mellar P. Davis 193
13 Methadone Mellar P. Davis Columba Quigley 211
14 Hydromorphone Columba Quigley Paul Glare 245
15 Levorphanol Mellar P. Davis 253
16 Diamorphine Janet R. Hardy Columba Quigley 263
17 Oxymorphone Paul Glare 269
18 Choice of opioids and the WHO ladder Paul Glare 275
19 Pharmacogenetics and opioids Joy R. Ross Columba Quigley 287
20 Opioid rotation Janet R. Hardy Columba Quigley Joy R. Ross 301
21 Equi-analgesia Mellar P. Davis Kenneth C Jackson II 313
22 Dosing strategies for acute pain Mellar P. Davis 329
23 Opioid dosing strategies for chronic pain and the management of opioid side effects Mellar P. Davis 347
24 Patient-controlled analgesia Mellar P. Davis 367
25 Spinal opioids in cancer pain Costantino Benedetti Steven Paquelet Mellar P. Davis 385
26 Opioid poorly responsive pain, physical dependence, tolerance, and opioid-induced hyperalgesia Mellar P. Davis 403
27 Opioids in special populations: developing countries MhoiraLeng 419
28 Opioids in special populations: paediatric population Ross Drake 431
29 Opioids in the terminal phase Janet R. Hardy 455
30 Cancer pain and substance abuse Kenneth L. Kirsh Tatiana D. Starr Lauren J. Rogak Steven D. Passik 461
Index 479
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