Notch from Neurodevelopment to Neurodegeneration : Keeping the Fate Book

Regulated intramembrane proteolysis - new lessons from lipid metabolism and the unfolded protein response.-Notch signaling in the brain: more than just a developmental story.-Control of notch activity by the ubiquitin-proteasome pathway.-A presenilin-dependent S3-like gamma-secretase cleavage of the beta-amyloid precursor protein.-New non-peptide inhibitors of gamma-secretase abolish A-beta production without modyfying notch cleavage.-Presenilins, APP, and notch: proteolysis from womb to tomb.-Missorting of the dendritic cell adhesion molecule telencephalin in presenilin-deficient neurons.-Beta-APP processing, its biology and Alzheimer's Disease.-Further analysis of the nicastrin: presenilin complex.-PS1 interacts with and facilitates beta-catenin turnover.-Delta-catenin, presenilin, and the synaptic-adherens junction complex.-Vascular smooth muscle cells are the primary target of the events leading from notch3 mutations to CADASIL.