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| Preface | ||
| Contributors | ||
| 1 | Synthesis of Polyampholyte Comb-Type Copolymers Consisting of a Poly(L-lysine) Backbone and Hyaluronic Acid Side Chains for DNA Carrier | 1 |
| 2 | Cationic [alpha]-Helical Peptides for Gene Delivery into Cells | 11 |
| 3 | Supramolecular Self-Assembly of Poly(ethylene glycol)-Block-Poly(L-lysine) Dendrimer with Plasmid DNA | 23 |
| 4 | Water-Soluble Cationic Methacrylate Polymers for Nonviral Gene Delivery | 35 |
| 5 | Stabilization of Polycation-DNA Complexes by Surface Modification with Hydrophilic Polymers | 61 |
| 6 | Use of Disulfide Cationic Lipids in Plasmid DNA Delivery | 79 |
| 7 | Interactions of Lipid-Oligonucleotide Conjugates with Low-Density Lipoprotein | 89 |
| 8 | Coupling of Nuclear Localization Signals to Plasmid DNA | 105 |
| 9 | Progress Toward a Synthetic Virus: A Multicomponent System for Liver-Directed DNA Delivery | 111 |
| 10 | Characterization of Polyampholyte Comb-Type Copolymer DNA Carriers | 123 |
| 11 | Methods for Studying the Formation of Polycation-DNA Complexes and Properties Useful for Gene Delivery | 131 |
| 12 | Characterization of DNA Condensates by Atomic Force Microscopy | 149 |
| 13 | Rapid and Systematic Transfer and Recovery of Large BACs/PACs into Mammalian Cells by HAEC Retrofitting | 159 |
| 14 | Systemic Delivery of Therapeutic Proteins by Intramuscular Injection of Plasmid DNA | 175 |
| 15 | Local Delivery of Therapeutic Proteins by Intratumoral Injection of Plasmid DNA-Lipid Complexes | 185 |
| 16 | Nonviral DNA Delivery from Polymeric Systems | 195 |
| 17 | Promotion of Duplex and Triplex DNA Formation by Polycation Comb-Type Copolymers | 209 |
| 18 | Lyophilization of Nonviral Gene Delivery Systems | 225 |
| 19 | Ultraviolet Absorption and Circular Dichroism Spectroscopy of Nonviral Gene Delivery Complexes | 253 |
| 20 | Characterization of Synthetic Gene Delivery Vectors by Infrared Spectroscopy | 285 |
| 21 | Characterization of Cationic Vector-Based Gene Delivery Vehicles Using Isothermal Titration and Differential Scanning Calorimetry | 319 |
| 22 | Light-Scattering Techniques for Characterization of Synthetic Gene Therapy Vectors | 349 |
| 23 | Renal Gene Therapy | 377 |
| Index | 393 |
| Price | Condition | Delivery | Seller | Action |
| $125.00 | Digital |
| WonderClub |
Tartar Kung
reviewed Nonviral Vectors for Gene Therapy on February 28, 2013
Nonviral Vectors for Gene Therapy
This is now one of my new favorite one volume histories of medicine. Even though it concentrates on the development of technology in medicine, and the author's underlying concern from the beginning is that physicians have sacrificed much of their personal relationship with the patient by adopting technology, it is a great and detailed discussion of auscultation, microscopy, the ophthalmoscope, the EKG, the roentgenogram, clinical chemistry and more. All histories must mention RTH Laennec, relate a tired discovery story, leave the reader to assume that the technology was adopted immediately and without complaint and then move on to the next item on the list, but Professor Reiser discusses the environment that the technology developed in, what the known probable sources were, who disliked or refused to use the new technology and why, and how and when it came to be used in common practice. All fascinating stuff; real history. This book was published in 1978 so its discussion of computers is dated in some ways, but in its essence nothing is really lost. As a personal complaint only, I think the book would be strengthened by more mention of the deleterious effects of the philosophy of mass automated screening of normal people - the false positives, the uncertain value to the patient of finding a true positive that might have had no effect on their life, whether a test is useful when it's clear that nothing can be done with the result, and what is sacrificed to pay for it all.
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