Neurobiology of Mental Illness Book

	Contributors
Pt. I	Introduction to Basic Neuroscience
	Introduction
1	Overview of Brain Development	3
2	Neurochemical Systems in the Central Nervous System	12
3	Using Basic Electrophysiology to Understand the Neurobiology of Mental Illness	29
4	Principles of Signal Transduction	41
5	Mechanisms of Neural Plasticity	66
6	Principles of Molecular Biology	76
7	Functional Genomics and Models of Mental Illness	87
Pt. II	Methods of Clinical Neurobiological Research
	Introduction
8	Contributions of Epidemiology to the Neurobiology of Mental Illness	103
9	Basic Methods for Clinical Molecular Genetics of Psychiatric Illness	112
10	Methods of Affective Clinical Psychophysiology	127
11	Clinical Neurochemistry	141
12	Clinical Neuroendocrinology	155
13	Neuroimmunology	171
14	Cognitive Neuroscience: Bridging Thinking and Feeling to the Brain, and Its Implications for Psychiatry	180
15	Neuroimaging Methodologies: Utilizing Radiotracers or Nuclear Magnetic Resonance	190
16	Methods of Postmortem Investigation of Human Brain	210
17	Drug Discovery and Development Methods for Mental Illness	221
Pt. III	Psychoses
	Introduction
18	Diagnostic Classification of the Psychoses: Historical Context and Implications for Neurobiology	237
19	Molecular Genetics of Schizophrenia	247
20	Animal Models of the Psychoses	263
21	Pharmacological Models of Psychoses	287
22	The Neurobiology of Schizophrenia	299
23	Functional Brain Imaging Studies in Schizophrenia	311
24	Psychophysiological and Information Processing Approaches to Schizophrenia	324
25	Principles of the Pharmacotherapy of Schizophrenia	339
Pt. IV	Mood Disorders
	Introduction
26	Diagnostic Classification of Mood Disorders: Historical Context and Implications for Neurobiology	357
27	Linkage and Association Studies of Bipolar Disorders	369
28	Animal Models of Mood Disorders	380
29	The Cellular Neurobiology of Bipolar Disorder	397
30	The Neurochemistry of Depressive Disorders: Preclinical Studies	421
31	The Neurochemistry of Depressive Disorders: Clinical Studies	440
32	Neuroimaging Studies of Mood Disorders	461
33	Principles of the Pharmacotherapy of Depression	491
34	Abnormalities of Brain Structure and Function in Mood Disorders Based Upon Postmortem Investigations	512
Pt. V	Anxiety Disorders
	Introduction
35	Diagnostic Classification of Anxiety Disorders: DSM-V and Beyond	525
36	Molecular Genetics of Anxiety	535
37	Animal Models of Anxiety Disorders	546
38	Structural and Functional Plasticity in the Hippocampal Formation: Stress, Adaptation, and Disease	558
39	Functional Neuroanatomy of Anxiety and Fear	584
40	The Neurobiology of Anxiety Disorders	605
41	The Neurobiology and Treatment of Obsessive-Compulsive Disorder	628
42	Neuroimaging Studies of Anxiety Disorders	639
43	Principles of Pharmacotherapy for the Anxiety Disorders	661
Pt. VI	Substance Abuse Disorders
	Introduction
44	Animal Models of Addiction	683
45	Cellular and Molecular Mechanisms of Drug Addiction	698
46	Genetic Epidemiology of Substance Use Disorders	710
47	Effects of Drugs of Abuse on Brain Development	720
48	Neuroimaging in Substance Abuse Research	740
49	Principles of the Pharmacotherapy of Substance Abuse Disorders	753
Pt. VII	Dementia
	Introduction
50	Diagnostic Classifications: Relationship to the Neurobiology of Dementia	771
51	The Molecular Biology of Alzheimer's Disease	783
52	Pharmacological and Transgenic Animal Models of Alzheimer's Disease	791
53	Functional Neuroanatomy of Learning and Memory	807
54	Neurochemical Systems Involved in Learning and Memory	813
55	Neuropathological and Neuroimaging Studies of the Hippocampus in Normal Aging and in Alzheimer's Disease	821
56	Abnormalities in Brain Structure on Postmortem Analysis of Dementia	836
57	Functional Brain Imaging Studies in Dementia	849
58	Principles of the Pharmacotherapy of Dementia	863
59	Cognitive Impairment in Demyelinating Disease	873
60	Dementia with Lewy Bodies
61	Dementia in Parkinson's Disease	896
Pt. VIII	Psychiatric Disorders of Childhood Onset
	Introduction
62	Developmental Neurobiology and the Childhood Onset of Psychiatric Disorders	921
63	Molecular Genetics of Childhood- and Adolescent-Onset Psychiatric Disorders	930
64	Neurobiology of Mental Retardation	944
65	The Neurobiology of Autism and the Pervasive Developmental Disorders	954
66	Tourette's Syndrome and Tic-Related Disorders in Children	968
67	Neurobiology of Attention Deficit Hyperactivity Disorder	979
68	The Neurobiology of Childhood Psychotic Disorders	1000
69	Neurobiology of Early-Onset Mood Disorders	1007
70	Childhood Anxiety Disorders: A Cognitive Neurobiological Perspective	1022
Pt. IX	Special Topic Areas
71	Neuropsychiatry: The Border Between Neurology and Psychiatry	1049
72	The Neurobiology of Personality and Personality Disorders	1062
73	The Neurobiology of Aggression	1076
74	Sexual Dysfunction and Pharmacological Treatments: Biological Interactions	1086
75	The Neurobiology of Social Attachment	1101
76	The Neurobiology of Eating Disorders	1112
77	The Neurobiology of Menstrual Cycle-Related Mood Disorders	1129
78	The Neurobiology of Circadian Rhythms	1140
79	The Neurobiology of Sleep in Relation to Mental Illness	1160
80	Depression, Cardiovascular Disease, and Cerebrovascular Disease: Implications for Pathophysiology and Treatment	1180
	Index	1193