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Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health Book

Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health
Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health, The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because, Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health has a rating of 2 stars
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Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health, The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because, Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health
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  • Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health
  • Written by author Chemical Industry Institute of Toxicology Staff, Fred J. Miller, Gary A. Boorman
  • Published by Taylor & Francis Inc, 1995/02/14
  • The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because
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Preface
Our Upper Airways and Our Ambient Air: A Historical Perspective 1
Research Strategy for Assessing Human Risk from Inhaled Nasal Toxicants 11
Nasal Toxicity: End Points of Concern in Humans 23
Nasal Dosimetry, Lesion Distribution, and the Toxicologic Pathologist: A Brief Review 41
Dosimetry Modeling: Approaches and Issues 59
Issues in Modeling Dosimetry in Rats and Primates 73
Nasal Dosimetry Modeling for Humans 85
In Vivo Measurements of Uptake 99
Modeling the Uptake of Gases by the Dog Nasal-Pharyngeal Region: Effects of Morphometric and Physicochemical Factors 113
Ozone Dosimetry Studies in the Nose and Eye Using Oxygen-18 125
Comparison of Four Biologically Based Dosimetry Models for the Deposition of Rapidly Metabolized Vapors in the Rodent Nasal Cavity 135
Nasal Dosimetry of Formaldehyde: Modeling Site Specificity and the Effects of Preexposure 159
Nasal Lesion Distribution and Toxicity in the Squamous Epithelial Region 177
Ozone-Induced Proliferative and Metaplastic Lesions in Nasal Transitional and Respiratory Epithelium: Comparative Pathology 187
Olfactory Mucosal Toxicity. Integration of Morphological and Biochemical Data in Mechanistic Studies: Dibasic Esters as an Example 205
Accessory Nasal Structures in Toxicology Studies 221
Human Olfactory Epithelium: Normal Patterns and Types of Lesions Found in the General Population 249
Toxicity of Nasal Respiratory Mucosa in Humans 277
Threshold Limit Values: How They are Established and Their Role in the Workplace 289
Management of Occupational Exposure Levels in the United States 293
Inhalation RfC Methodology: Dosimetric Adjustments and Dose-Response Estimation of Noncancer Toxicity in the Upper Respiratory Tract 301
U.S. EPA Inhalation Reference Concentration for Bromomethane 327
Evaluation of Nasal Tract Lesions in Derivation of the Inhalation Reference Concentration for Hexamethylene Diisocyanate 341
Poster Abstracts 357
Index 465


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Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health, The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because, Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health

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Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health, The location and severity of toxic responses in the noses of laboratory animals following inhalation of various compounds is attracting a growing number of researchers. This interest has arisen not only due to types of responses observed, but also because, Nasal Toxicity and Dosimetry of Inhaled Xenibiotics : Implications for Human Health

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