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Contributing Authors xiii
Series Preface xxiii
Preface xxv
Current Concepts in the Anatomy and Physiology of the Basal Ganglia 1
1 Functional Anatomy and Pathophysiology of the Basal Ganglia Jonathan M. Brotchie José A. Obeso 1
Parkinson's Disease 15
2 Genetics of Parkinson's Disease-An Overview Christine Klein 15
3 α-Synuclein and Parkinson's Disease Thomas Gasser 40
4 PARK2: Parkin Mutations Responsible for Familial Parkinson's Disease Nobutaka Hattori Taku Hatano Yutaka Machida Shigeto Sato Shin-Ichiro Kubo 54
5 PINK1(PARK6) and Parkinson's Disease Enza Maria Valente Alessandro Ferraris 66
6 DJ-1 (PARK7) and Parkinson's Disease Vincenzo Bonifati 83
7 LRRK2 and Parkinson's Disease Matthew James Farrer 102
8 Environmental Factors and Parkinson's Disease Caroline M. Tanner 113
9 Pathology of Parkinson's Disease Glenda Halliday Karen Murphy 132
10 Pathogenesis of Parkinson's Disease Amitabh Gupta Ted M. Dawson 155
11 Imaging in Parkinson's Disease David James Brooks 170
12 Dementia in Parkinson's Disease David John Burn 188
13 Psychiatric Issues in Parkinson's Disease Daniel Weintraub 213
14 Nonmotor Aspects of Parkinson's Disease Eduardo Tolosa Joan Santamaria Carles Gaig Yaroslau Compta 229
15 Therapy of the Motor Features of Parkinson's Disease Susan Fox Anthony E. T. Lang 252
16 Surgical Therapy for Parkinson's Disease Adrian W. Laxton Clement Hamani Andres M. Lozano 273
17 Cell-Based and Gene-Based Therapy for Parkinson's Disease C. Warren Olanow 287
l8 Neuroprotection in Parkinson's Disease Anthony H.V. Schapira 301
Multiple System Atrophy 321
19 Etiology, Pathology, and Pathogenesis Felix Geser Kurt Jellinger Martin Köllensperger Nadia Stefanova Gregor K. Wenning 321
20 Multiple System Atrophy: Clinical Features and Management Werner Poewe Klaus Seppi 340
Progressive Supranuclear Palsy 361
21 Progressive Supranuclear Palsy Huw R. Morris 361
Corticobasal Ganglionic Degeneration 375
22 Corticobasal Ganglionic Degeneration Keith A. Josephs, Jr. 375
Frontotemporal Dementia 397
23 Frontotemporal Dementia Christian W. Wider Dennis W. Dickson Rosa Rademakers Zbiginiew K. Wszolek 397
Huntington's Disease 417
24 Etiology, Pathology, and Pathogenesis Patrick Weydt G. Bernhard Landwehrmeyer Albert C. Ludolph 417
25 Clinical Features and Care Ira Shoulson 432
The Dystonias 457
26 The Genetics and Pathogenesis of Dystonia Thomas T.Warner 457
27 Management Elena Moro Marie Vidailhet 474
Other Movement Disorders 489
28 Paroxysmal Dyskinesias Kailash P. Bhatia Susanne A. Schneider 489
29 Essential Tremor and Other Tremors Günther Deuschl Alfonso Fasano 506
30 Other Choreas Ruth H. Walker 558
31 Restless Legs Syndrome Wayne Hening Claudia Trenkwalder 587
32 Startled People Philip Thompson 622
33 Psychogenic Movement Disorders Madhavi Thomas Joseph Jankovic 630
34 Tics and Gilles de la Tourette Syndrome Harvey S. Singer 651
Index 665
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Movement Disorders 4: Blue Books of Neurology Series, Volume 35, Movement Disorders 4, the newest volume in the Blue Books in Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and pharmacologic treatment on the full range of movement disorders.
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Movement Disorders 4: Blue Books of Neurology Series, Volume 35, Movement Disorders 4, the newest volume in the Blue Books in Neurology series provides you with rapid access to practical, clinical guidance on the diagnosis and pharmacologic treatment on the full range of movement disorders.
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