Molecular Neurobiology of Alzheimer Disease and Related Disorders Book

	Foreword
	Preface
	Methods of regulating Alzheimer pathogenesis : diet, oxidative damage and inflammation	1
	The RNA-binding protein causes aberrant splicing of presenilin-2 pre-mRNA in sporadic Alzheimer's disease	17
	Alzheimer's [gamma]-secretase mechanism produces amyloid-[beta]-protein like peptides simultaneously with release of intracellular signaling fragments	31
	Pivotal role of neurofibrillary degeneration in Alzheimer disease and therapeutic targets	42
	Tau pathology of sporadic tauopathies
	Deregulation of GSK-3[beta] and JNK in a mouse model of tauopathy : a kinase combination that induces Alzheimer-type tau hyperphosphorylation	62
	Clinical assessment of the genetic risk functions in Alzheimer's disease	71
	Hydrogen sulfide is severely decreased in Alzheimer disease brains	79
	Functional analysis of the presenilin complex and [gamma]-secretase activity
	Pharmacogenomic studies with a combination therapy in Alzheimer's disease	94
	Nicotinic receptor stimulation blocks neurotoxicity induced by amyloid-[beta] via the phosphatidylinositol-3-kinase cascade	108
	Involvement of unfolded protein responses in Alzheimer's disease	123
	Advances in the development of biomarkers for Alzheimer's disease - from CSF total tau and amyloid-[beta]-(1-42) proteins to phosphorylated tau and amyloid-[beta]-antibodies	134
	Genetic analysis of familiar Alzheimer's disease in a Japanese population	157
	Oxidative stress in Alzheimer disease : the earliest cytological and biochemical feature	164
	Neurogenesis : a promising therapeutic target for Alzheimer disease and related disorders	172
	Learning deficits in N279K tau transgenic mice and an assembly model of tau protein	183
	Animal models of tauopathies	195
	Aberrant splicing of tau transcripts in frontotemporal dementia with Parkinsonism linked to chromosome 17	205
	Tau filament formation and associate memory deficit in aged mice expressing mutant (R406W) human tau
	Activated protein kinases and phosphorylated tau protein in Alzheimer disease	225
	A functional genomics approach to the analysis of biological markers in Alzheimer disease	236
	Epilogue	286
	Author index	289
	Subject index	291