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Introduction | 1 | |
Ch. 1 | Reorganization of the Genome during Aging of Proliferative Cell Compartments | 21 |
Ch. 2 | Genomic Instability during Aging of Postmitotic Mammalian Cells | 71 |
Ch. 3 | DNA Repair during Aging | 137 |
Ch. 4 | Changes in Gene Expression during Aging of Mammals | 183 |
Ch. 5 | Role of Mitochondria in Cell Aging | 219 |
Ch. 6 | Modifications of the Cell Surface Leading to Cell Elimination | 237 |
Ch. 7 | Protein Kinase C Signal Transmission during Aging | 269 |
Ch. 8 | Changes in Transmembrane Signaling Mechanisms during Aging: Cellular and Molecular Aspects | 293 |
Ch. 9 | Structural Changes Modifying the Intracellular Flow of Information | 307 |
Ch. 10 | The Aging of the Neuronal Cytoskeleton | 327 |
Ch. 11 | Transport of mRNA into the Cytoplasm | 353 |
Ch. 12 | Translational and Post-translational Modifications during Aging | 389 |
Ch. 13 | Carbonyl Toxification Hypothesis of Biological Aging | 421 |
Ch. 14 | Amyloidosis and Aging | 437 |
Ch. 15 | Extracellular Matrix | 459 |
Ch. 16 | Brain Metabolism during Aging | 493 |
Ch. 17 | Central Neurotransmission in the Elderly | 511 |
Ch. 18 | Age-Related Changes in Neuropeptidergic Neurons in the Human Hypothalamus | 527 |
Index | 533 |
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