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Preface vii
Contributors xi
List of Color Plates xiii
An Overview of Compounds That Interact with Tubulin and Their Effects on Microtubule Assembly Ernest Hamel 1
Molecular Mechanisms of Microtubule Acting Cancer Drugs John J. Correia Sharon Lobert 21
Microtubule Dynamics: Mechanisms and Regulation by Microtubule-Associated Proteins and Drugs In Vitro and in Cells Mary Ann Jordan Leslie Wilson 47
Microtubule Associated Proteins and Microtubule-Interacting Proteins: Regulators of Microtubule Dynamics Maria Kavallaris Sima Don Nicole M. Verrills 83
The Post-Translational Modifications of Tubulin Richard F. Luduena Asok Banerjee 105
The Isotypes of Tubulin: Distribution and Functional Significance Richard F. Luduena Asok Banerjee 123
The Tubulin Superfamily Richard F. Luduena Asok Banerjee 177
Tubulin Proteomics in Cancer Pascal Verdier-Pinard Fang Wang Ruth Hogue Angeletti Susan Band Horwitz George A. Orr 193
Tubulin and Microtubule Structures Eva Nogales Kenneth H. Downing 211
Destabilizing Agents: Peptides and Depsipeptides Lee M. Greenberger Frank Loganzo 227
Molecular Features of the Interaction of Colchicine and Related Structures with Tubulin Susan L. Bane 259
Antimicrotubule Agents That Bind Covalently to Tubulin Dan L. Sackett 281
Microtubule Stabilizing Agents Susan Band Horwitz Tito Fojo 307
Mechanisms of Resistance to Drugs That Interfere with Microtubule Assembly Fernando Cabral 337
Resistance to Microtubule-Targeting Drugs Paraskevi Giannakakou James P. Snyder 357
Microtubule Stabilizing Agents in Clinical Oncology: The Taxanes Chris H. Takimoto Muralidhar Beeram 395
Investigational Anticancer Agents Targeting the Microtubule Lyudmila A. Vereshchagina Orit Scharf A. Dimitrios Colevas 421
Microtubule Damaging Agents and Apoptosis Manon Carre Diane Braguer 479
Microtubule Targeting Agents and the Tumor Vasculature Raffaella Giavazzi Katiuscia Bonezzi Giulia Taraboletti 519
Neurodegenerative Diseases: Tau Proteins in Neurodegenerative Diseases Other Than AD Andre Delacourte Nicolas Sergeant Luc Buee 531
Structure, Function, and Regulation of the Microtubule Associated Protein Tau Janis Bunker Stuart C. Feinstein 559
Index 577
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Add Microtubule Targets in Cancer Therapy, This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and invest, Microtubule Targets in Cancer Therapy to the inventory that you are selling on WonderClubX
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Add Microtubule Targets in Cancer Therapy, This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and invest, Microtubule Targets in Cancer Therapy to your collection on WonderClub |