Microbial DNA and Immune Modulation Book

Part I. Introduction

Immunostimulatory DNA: An Overview

Eyal Raz

Historical Perspectives

Saburo Yamamoto, Toshiko Yamamoto, and Tohru Tokunaga

Part II. Receptors and Signaling

Signal Transduction Pathways Activated by CpG-DNA

Hans Häcker

A Novel Toll-Like Receptor that Recognizes Bacterial DNA

Hiroaki Hemmi and Shizuo Akira

Activation of Innate Immunity by Microbial Nucleic Acids

Wen-Ming Chu, Xing Gong, and Tony Yoon

Phosphorothioate Backbone Modification Changes the Pattern of Responses to CpG

Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. Hume

Part III. Cell Activation

Activation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and Human

Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, and Tohru Tokunaga

Regulation of Antigen Presenting Cell Function by CpG-DNA

David Askew, Rose S. Chu, and Clifford V. Harding

Activation of B Cells by CpG Motifs in Bacterial DNA, Ae-Kyung Yi and Arthur M. Krieg

IFN-Dependent Pathways for Stimulation of Memory CD8+ Cells

Jonathan Sprent

Cross Priming of CD8+ T Cells by Immunostimulatory Sequence DNA

Hearn Jay Cho, Sandip Datta, and Eyal Raz

Part IV. Vaccination Strategies

The Th1 Adjuvant Effect of Immunostimulatory DNA Sequences

Maripat Corr and Chih Min Tang

Immunostimulatory DNA Pre-Priming for the Induction of Th1 and Prevention of Th2 Biased Immune Responses

Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, and Anthony A. Horner

Protein-Immunostimulatory DNA-Conjugate: A Novel Immunogen

Kenji Takabayashi, Helen Tighe, Lucinda Beck, and Hans L. Spiegelberg

Immunostimulatory DNA Sequence-Based Mucosal Vaccines

Anthony A. Horner

Enhancement of the Immunoadjuvant Activity of Immunostimulatory DNA Sequence by Liposomal Delivery

Eli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, and Yechezkel Barenholz.

Immunostimulatory Sequences in Plasmid Vectors

Christina C. N. Wu, Chih Min Tang, Brian Crain, and Maripat Corr

Part V. Applications-Infectious Disease

Comparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis B

Michael J. McCluskie, Risini D. Weeratna, and Heather L. Davis

Immunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?

Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, and Eyal Raz

Immunoprotective Activity of CpG Oligonucleotides

Dennis M. Klinman, Ken J. Ishii, and Ihsan Gursel

Protective Immunity of Immunostimulatory Sequences Against Mycobacterial Infection

Tomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, and Antonino Cantanzaro

Part VI. Applications-Allergy

DNA-Based Immunotherapeutics for Allergic Disease

Anthony A. Horner and Eyal Raz

Immunostimulatory DNA for Allergic Asthma

Reid K. Ikeda, Kenji Takabayashi, and David Broide

CpG Oligodeoxynucleotides in Asthma

Kunihiko Kitagaki and Joel N. Kline

Modulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence Oligonucleotides

Andrea Keane-Myers and Chi-Chao Chan

Part VII. Applications-Cancer

CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma

Thomas L. Warren and George J. Weiner

Part VIII. Inflammation and Autoimmunity

The Antigenicity of Bacterial DNA

David S. Pisetsky

Inflammatogenic Properties of Immunostimulatory DNA Sequences

Andrej Tarkowski, L. Vincent Collins, Guo-Min Deng, and Leno Mölne

The Role of Immunostimulatory DNA Sequences in Arthritis

Sarah T.A. Roord, Arash Ronaghy, Berent J. Prakken, Kenji Takabayashi, and Dennis A. Carson

Effects of Immunostimulatory DNA Oligonucleotides on Experimental Colitis

Daniel Rachmilewitz, Fanny Karmeli, Leonor Leider-Trejo, Kenji Takabayashi, Tomoko Hayashi, and Eyal Raz

Part IX. Safety Considerations

CpG ODN: Safety Considerations

Daniela Verthelyi and Dennis M. Klinman

Index