Ion channels in the cardiovascular system Book

	List of Contributors
	Preface
	Acknowledgments
	Introduction: Ion Channels and Cardiology - The Need for Bridges Across a Widening Boundary
Pt. 1	Ion Channels and Cardiac Disease: Dimensions of the Problem
1	Antiarrhythmic Implications from the CAST Trial: Impetus for New Directions	3
2	Epidemiology of Sudden Cardiac Death: Population Characteristics, Conditioning Risk Factors, and Dynamic Risk Factors	15
3	Autonomic Markers for Sudden Cardiac Death	35
4	Autonomic Mechanisms Underlying Arrhythmogenesis and Sudden Cardiac Death in Ischemic Heart Disease	61
Pt. 2	Ion Channels and Cardiovascular Function
5	Cardiac Electrogenesis and the Sodium Channel	81
6	Calcium Channels as Biosensors of Cellular Energy Metabolism: Effects of Magnesium and MgATP	101
7	Delayed Rectifier Potassium Channels of Cardiac Muscle	121
8	Cardiac Inward Rectifier Potassium Channel	145
9	Molecular Physiology of cAMP-Dependent Chloride Channels in Heart	169
10	Cardiovascular Gap Junctions: Gating Properties, Function, and Dysfunction	185
Pt. 3	Channel Modulation and Autonomic Control
11	[actual symbol not reproducible] Effects on Potassium Currents and Membrane GTPase in Single Rabbit Cardiac Cells	221
12	[beta]-Adrenergic Modulation of Cardiac Calcium Channel Gating	237
13	Probing Potassium Channel Pores	253
Pt. 4	Structure and Function of Ion Channels
14	Mechanisms of Potassium Channel Gating Probed by Site-Directed Mutagenesis	271
15	Molecular Physiology of Voltage-Gated Potassium and Sodium Channels: Ion Channel Diversity within the Cardiovascular System
16	Structure and Modulation of Voltage-Gated Sodium Channels	317
17	Extracellular Potassium Modulates a Transient Potassium Current in Rat Atrial Cells	341
18	Physiological and Molecular Insights into Excitation-Contraction Coupling in Cardiac and Skeletal Muscle	355
19	Functional Expression of Cardiac and Smooth Muscle Calcium Channels	369
Pt. 5	Molecular Pharmacology
20	Conformation-Dependent Drug Binding to Cardiac Potassium Channels	387
21	Block of Myocardial Potassium Channels by Antiarrhythmic Drugs: Dependence on Channel Gating	415
22	Dihydropyridine Modulation of Cardiovascular L-Type Calcium Channels: Molecular and Cellular Pharmacology	425
23	Calcium Antagonist Binding Domains of L-Type Calcium Channels	441
Pt. 6	Drug Discovery
24	Strategies to Discover Novel Ion Channel Modulators	463
25	The Design of New Calcium Antagonists	489
26	Inhibitors of Cardiac-Delayed Rectifying Potassium Currents as Potential Novel Antiarrhythmic Agents	509
27	Role of Ion Channels in Antiarrhythmic and Antifibrillatory Drug Action	529
Pt. 7	Research Recommendations
28	Report of the Research Assessment Panel Convened by the National Heart, Lung, and Blood Institute, Chantilly, VA, Conference: "Ion Channels in the Cardiovascular System" (September 12-15, 1992)	565
	Index	573