Heterocycles in Natural Product Synthesis Book

Preface

PART I: Strained Heterocycles in the Synthesis of Natural Products

AZIRIDINES IN NATURAL PRODUCT SYNTHESIS Introduction Synthesis of Natural Products Containing Aziridine Units Synthesis of Natural Products Involving the Transformation of an Aziridine Moiety Conclusions

AZETIDIINE AND ITS DERIVATIVES Introduction Structural Description of Azetidines Synthetic Methodologies for the Formation of Azetidine Rings Synthesis of Mugineic Acids Synthesis of Penaresidins Structural Description of Azetidin-2-ones Synthetic Methodologies for the Formation of Azetidin-2-ones Synthesis of Penicillin Synthesis of Cephalosporin Conclusion

EPOXIDES AND OXETANES Introduction Epoxides in Natural Product Synthesis Oxetane in Natural Product Synthesis Conclusion

PART II: Common Ring Heterocycles in Natural Product Synthesis

FURAN AND ITS DERIVATIVES Introduction Natural Products Containing the Furan Ring Furan Derivatives as Reagents in the Synthesis of Natural Products Summary

PYRAN AND ITS DERIVATIVES Introduction Application of Pyran Moieties in the Synthesis of Natural Products Conclusion

PYRROLE AND ITS DERIVATIVES Introduction Synthesis of Pyrrole Natural Products Synthesis of Non-pyrrole Natural Products from Pyrrole Derivatives Conclusion

INDOLES AND INDOLIZIDINES Introduction Applications of Indoles and Indolizidines in the Synthesis of Natural Products Conclusion

PYRIDINE AND ITS DERIVATIVES Introduction Application of the Pyridine Moiety in the Synthesis of Natural Products Conclusion

QUINOLINES AND ISOQUINOLINES Introduction Application of Quinolines and Isoquinolines in the Synthesis of Natural Products Conclusion

CARBAZOLES AND ACRIDINES Introduction to Carbazoles Total Synthesis of Carbazole Alkaloids Introduction to Acridines Synthesis of Acridines and Acridones

THIOPHENE AND OTHER SULFUR HETEROCYCLES Introduction Synthesis of Natural Products Containing Thiophene Synthesis of Natural Products Containing Other Sulfur Heterocycles Conclusion

OXAZOLE AND ITS DERIVATIVES Introduction Mono-Oxazoles Unconnected Bis- and Tris-Oxazoles Cyclic Polyheterocyclic Metabolites Containing Single Oxazole Residues Conjugated Bis-Oxazoles Tris- and Poly-Oxazoles

THIAZOLINE AND THIAZOLE AND THEIR DERIVATIVES Introduction General Methods for the Synthesis of Thiazoline and Thiazole Derivatives Thiazole and Thiazoline-Containing Natural Products Conclusions

PYRIMIDINE AND IMIDAZOLE General Introduction Pyrimidine-Based Natural Products Imidazole-Based Natural Products Conclusion

PART III: Natural Products Containing Medium and Large Ring-Sized Heterocyclic Systems

OXEPINES AND AZEPINES Introduction Synthesis of the Heterocyclic Core of Selected Natural Products Containing Oxepines Synthesis of the Heterocyclic Core of Selected Natural Products Containing Azepines Synthesis of the Heterocyclic Core of Selected Natural Products Containing Oxazapines Conclusion

BIOACTIVE MACROCYCLIC NATURAL PRODUCTS General Natural Products Containing Azoles Pyridine- and Piperidine-Containing Natural Products Indole- and Imidazole-Containing Natural Products Pyran- and Furan-Containing Natural Products Piperazic Acid-Containing Natural Products Mixed Heterocyclic Systems Conclusions