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| List of Figures | ||
| List of Tables | ||
| Preface | ||
| Acknowledgments | ||
| Introduction | 1 | |
| 1 | Neuroanatomy of the GnRH-1 System | 9 |
| Hypophysiotropic GnRH-1 Neurons: Neuroanatomy | 11 | |
| GnRH in Mast Cells in the Brain | 21 | |
| GnRH Cells in the Peripheral Nervous System | 23 | |
| GnRH Cells Outside the Nervous System | 24 | |
| 2 | GnRH Pulsatility | 29 |
| In Vivo Measurements of Pulsatile GnRH Release | 30 | |
| Electrophysiology of GnRH Neurons in Vivo | 38 | |
| In Vitro Measurements of GnRH Pulsatility | 42 | |
| How are GnRH Pulses Coordinated? | 49 | |
| 3 | GnRH Neurons: Changes Across the Life Cycle | 53 |
| Embryonic Development of GnRH Neurons | 54 | |
| The Role of GnRH Neurons in Pubertal Development | 61 | |
| The Role of GnRH Neurons in Adulthood | 80 | |
| Reproductive Aging | 85 | |
| 4 | Factors Regulating GnRH Neurons | 93 |
| Neurotransmitters and Neuromodulators Regulating GnRH Neurons | 94 | |
| Neurotrophic Factors and Cytokines Regulating GnRH Neurons | 118 | |
| Are Steroid Hormone Receptors on GnRH Neurons? | 121 | |
| 5 | The GnRH Gene | 125 |
| Structure & Processing of the GnRH-1 Gene | 125 | |
| GnRH 5' Flanking Region and Gene Transcription | 127 | |
| Regulation of GnRH Gene Expression in Vivo | 131 | |
| Post-Transcriptional Regulation of GnRH mRNA Levels | 150 | |
| FOS Expression in GnRH Neurons | 151 | |
| 6 | Multiple GnRH Molecules, Phylogeny and Evolution | 157 |
| Amino Acid and Gene Sequences and Structures of GnRH | 159 | |
| Co-Existence of Multiple GnRHS in Vertebrate Brains | 161 | |
| GnRH in Invertebrates | 168 | |
| Evolution of GnRH | 170 | |
| How Ancient is GnRH? | 173 | |
| 7 | GnRH Neurons and Reproductive Behavior | 175 |
| Effects of GnRH on Sexual Behavior in Females | 175 | |
| Effects of GnRH on Sexual Behavior in Males | 177 | |
| Species Comparisons | 178 | |
| Neurotransmitters Involved in Effects of GnRH on Reproductive Behaviors | 178 | |
| Effects of Behavior on GnRH Expression | 179 | |
| 8 | GnRH Neuronal Cell Lines | 183 |
| The Creation and Properties of the Immortalized GnRH Cell Lines | 183 | |
| Neurotransmitters Regulating GnRH Cell Lines | 189 | |
| Second Messengers and Signal Transduction in GnRH Cell Lines | 195 | |
| Neurotrophic Factors and Cytokines Regulating GnRH Cell Lines | 198 | |
| Peripheral Proteins Regulating GnRH Cell Lines | 201 | |
| Do GnRH Cell Lines Express Steroid Hormone Receptors? | 201 | |
| Caveats of Immortalized GnRH Cell Lines | 203 | |
| 9 | GnRH Mutants and Transgenic Mice | 205 |
| GnRH Transgenic Animals | 205 | |
| The Hypogonadal (HPG) Mouse | 211 | |
| 10 | GnRH in Humans | 217 |
| Localization and Morphology of Human GnRH-1 Neurons | 217 | |
| Pulsatile GnRH/LH Release in Humans | 218 | |
| Molecular Biology of GnRH in Humans | 222 | |
| GnRH Therapy | 223 | |
| GnRH Agonists and Antagonists | 226 | |
| Bibliography | 229 | |
| Index | 317 |
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Add Gnrh: The Master Molecule of Reproduction, Gonadotropin-releasing hormone (GnRH) cells are the key regulators of reproductive function in all vertebrate organisms. The GnRH molecule is synthesized in a small number of neurons in rostral hypothalamic regions of the brain. In mammals, these neurons , Gnrh: The Master Molecule of Reproduction to the inventory that you are selling on WonderClubX
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Add Gnrh: The Master Molecule of Reproduction, Gonadotropin-releasing hormone (GnRH) cells are the key regulators of reproductive function in all vertebrate organisms. The GnRH molecule is synthesized in a small number of neurons in rostral hypothalamic regions of the brain. In mammals, these neurons , Gnrh: The Master Molecule of Reproduction to your collection on WonderClub |