Germ Cell Tumours V Book

	Preface
	Acknowledgements
1	The Genetics of Testicular Germ Cell Tumours	1
2	Advances in the Understanding of Germ Cell Tumour Biology	23
3	A Notch-related Gene Located on the Long Arm of Human Chromosome 12	30
4	Investigating Gain of 12p Material in Testicular Germ Cell Tumours and Its Apparent Absence in Carcinoma in situ	32
5	Overrepresentation of the Short Arm of Chromosome 12 Is Related to Invasive Growth of Testicular Seminomas and Non-seminomas	34
6	Reactivity of Germ Cell Maturation Stage-specific Markers in Classical and Spermatocytic Seminoma	38
7	Expression of Human endogenous Retroviruses HERV-K/HTDV in Germ Cell Tumours: Possible Biological Role and Clinical Application	43
8	No Association Between HLA Class II Genes and Testicular Germ Tumour (TGCT) with Genotyping of the HLA-Region on Chromosome 6p21 and Haplotype Sharing Analysis	45
9	RT-PCR for AFP, HCG, GCAP and PDGF-1 To Detect Circulating Tumour Cells in Testicular Germ Cell Tumours	47
10	The Prognostic Significance of Tumour Infiltrating Lymphocyte Count in Stage I Testicular Seminoma Managed by Surveillance	49
11	HIV Related Testicular Cancer	51
12	Microinvasive Testicular Germ Cell Tumours: Prevalence in Stage I Tumours	53
13	Serum Lactate Dehydrogenase Isoenzyme 1 in Patients with Testicular Seminoma or Nonseminoms Stage I: Two Nationwide Danish Studies of Surveillance	55
14	The Atrophy Hypothesis and Development of Malignant Germ Cell Cancers of the Testis	57
15	Prognosis and Prognostic Factors	63
16	Role of the Human Apurinic Endonuclease Apel/Ref-1 in Germ Cell Tumours	76
17	Translational Implications of Apel in Germ Cell Tumours: Apel as a Therapeutic Target	85
18	Current Clinical Trials in Germ Cell Tumours in the United States	95
19	Topoisomerase I and II in Germ Cell Cancer as Indicators of Possible Drug Selection for Salvage Chemotherapy Studies	99
20	Overview of Female Germ Cell Tumours	103
21	Germ Cell Tumours of the Ovary: a Clinicopathological Study of 121 Cases from Nepal	112
22	Serum Lactate Dehydrogenase Isoenzyme 1 in Patients with Testicular and Ovarian Germ Cell Tumours	114
23	Low Dose Bleomycin Every Three Weeks with Cisplatin and Etoposide Results in Excellent Event Free and Survival Rates for Children and Adolescents with Gonadal Malignant Germ Cell Tumours (MGCT): A POG/CCG Intergroup Report	119
24	Treatment Strategy for Childhood Extracranial Secreting Germ Cell Tumours Based on Alphafoetoprotein (AFP) Level: Protocol TGM95 of the Societe Francaise d'Oncologie Pediatrique (SFOP)	121
25	Risk Factors in Malignant Extracranial Germ Cell Tumours (MGCTs) of Childhood: Analysis of UKCCSG's GCII Study	123
26	A Watch-and-Wait-Strategy Is a Safe Procedure in Children and Adolescents with Malignant Non-testicular Germ Cell Tumours (GCTs): Results of the German Consecutive MAKEI 83/86/89 and 96 Protocols	125
27	Mediastinal Germ Cell Tumours (MGCT) in Children and Adolescents: Age Correlates with Histological Differentiation, Genetic Profiles and Clinical Outcome	127
28	Intracranial Malignant Germ Cell Tumours (CNS GCTs): Interim Results of the SIOP Trial	129
29	Treatment of Primary Intracranial Germ Cell Tumours with Carboplatin-based Chemotherapy and Focal Irradiation	131
30	Patterns of Relapse Following Focal Irradiation of Intracranial Germinoma: Critical Review of TGM-TC90 SFOP Protocol	132
31	Impact of Residual Lesions in Intracranial Germinoma- Interim Results from the SIOP CNS GCT 96 Study	133
32	Failure of Treatment in Childhood Extracranial and Extratesticular Malignant Germ Cell Tumours (MGCT)	135
33	Surgery for Germ Cell Tumours: Current Status in the USA	139
34	Surgery for Testicular Cancer: UK and European Experience	147
35	Resection of Residual Masses: a Decade of Research with Jan Keizer	154
36	Predictive Factors for Residual Teratoma after Chemotherapy for Non- seminomatous Germ Cell Tumours (NSGCT)	157
37	Orchidectomy Following Chemotherapy for Patients with Metastatic Testicular Germ Cell Cancer	159
38	Organ Sparing Tumour Resection in Testicular Germ Cell Tumours (TGCT) - Long-term Follow-up	161
39	Chemotherapy for Testis Conservation in Patients with Germ Cell Cancer (GCC): Is It Safe and Could Combination with Tumour Enucleation Increase the Frequency of Success?	163
40	How Valid Is a Prediction Rule for Residual Retroperitoneal Mass Histology in NSGCT?	165
41	Minimizing Morbidity from Surgery for Non-seminoma Testicular Cancer	166
42	Quality of Life in Patients with Good Prognosis Metastatic Germ Cell Tumours: Comparison of Four Chemotherapy Schedules (EORTC 30941 / MRC TE20)	183
43	Introducing the Measurement of Quality of Life into Clinical Practice: Technology and Mechanisms	196
44	Mortality Rates in Patients with Malignant Germ Cell Tumours (MGCT) with Emphasis on Second Cancer and Cardiovascular Mortality	209
45	Cardiovascular Disease as a Long Term Complication of Treatment for Testicular Cancer	211
46	Fertility and Quality of Life after Treatment for Testicular Cancer	213
47	The Prevalence of Avascular Necrosis in Patients Treated with Chemotherapy for Testicular Tumours	215
48	Factors Assocated with Bleomycin Lung Toxicity in Germ Cell Tumour Patients Treated at the Royal Marsden Hospital Between 1982 and 1999	217
49	The Provision of an Adolescent Service to Patients Aged up to 25 Years Attending the Germ Cell Tumour Service, Leeds	219
50	Chemotherapy for Germ Cell Tumours in the United States	223
51	The Current Status of Radiotherapy in the Management of Germ Cell Tumours	228
52	Limited Volume Short Course Radiation for Stage I Seminoma of the Testis	233
53	A Randomised Trial of Two Radiotherapy Schedules in the Adjuvant Treatment of Stage I Seminoma (MRC TE18) - Preliminary Report	235
54	Metastatic Seminoma: Should Treatment Be Different from Non-seminoma?	237
55	GAMEC - a Novel Protocol for IGCCCG Poor Prognosis and Relapsing Germ Cell Tumours	240
56	Adjuvant Chemotherapy in High-risk Stage I Non-seminomatous Germ Cell Tumours: the Spanish Germ Cell Cancer Group Experience	242
57	Single Agent Carboplatin for Advanced Seminoma: Effective Initial Therapy	243
58	Bleomycin in Combination Chemotherapy of Testicular or Extragonadal Germ Cell Tumours: a Review of Published Trials	244
59	Long Term Follow Up of Anglian Germ Cell Cancer Group Studies of Chemotherapy for Stage I Non Seminoma	247
60	Radiation Risk in the Follow-up of Early Stage Germ Cell Tumours and Newer Imaging Modalities	251
61	FDG PET Scanning in Germ Cell Tumours	257
62	Vascular Anomalies in Patients Undergoing Retroperitoneal Lymph Node Dissection (RPLND) for Testicular Germ Cell Tumours (TGCT)	268
63	The 5 Year Experience of a Rapid Access Diagnostic Testicular Swelling Clinic	270
64	Negative Predictive Value of "Clean Retroperitoneum" by Ultrasound in Patients with Testicular Cancer	271
65	Multivariate Analysis of Predictive Factors of Late Relapse in 1264 Patients with Testicular Germ Cell Tumours	273
66	Risks and Benefits of Follow-up of Early Germ Cell Tumours - a Survey of Current Practice	275
67	Survey of the Management of Brain Metastases from Malignant Germ Cell Tumours on Clinical Presentation	277
	Index	279