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Preface | ||
Acknowledgments | ||
1 | Introduction | 1 |
I | Medical Thinking | 9 |
2 | Inborn Errors and Chemical Individuality | 11 |
3 | The Transition from Oslerian to Garrodian Medicine | 17 |
4 | Individuality and Causes | 29 |
5 | Definitions of Disease | 37 |
II | A Logic of Disease | 45 |
6 | Biology and Medicine: Contrasts and Convergences | 47 |
7 | A Synthesis | 57 |
III | Species Identity | 63 |
8 | Lessons from Phylogeny | 65 |
IV | Adaptive Flexibility: Homeostasis and Development | 73 |
9 | Physiological Homeostasis: The Homeostasis of the Moment | 77 |
10 | Genetic Homeostasis: The Past | 92 |
11 | Developmental Homeostasis: The Lifetime | 101 |
12 | Sociocultural Homeostasis | 114 |
13 | Homeostatic Interactions | 122 |
V | Descent with Modification: Genetic Variation | 131 |
14 | What Is a Gene? | 133 |
15 | The Paths of Gene Action | 146 |
16 | Whatever, Is, Is Variable | 152 |
17 | The Semantics of Genetics | 159 |
18 | Classification of Disease | 166 |
VI | Reproduction, Frequency, and Continuity | 175 |
19 | The Diploid State | 177 |
20 | Gene Frequency | 184 |
21 | Heterogeneity | 191 |
22 | Unity and Continuity of Disease | 201 |
23 | Heritability | 225 |
24 | Infections | 234 |
VII | An Analysis of Disease in Three Time Frames | 241 |
25 | The Moment: Type I Diabetes | 243 |
26 | The Lifetime | 248 |
27 | Biological and Social History, and a Vision of Disease in Three Time Frames | 256 |
VIII | The Logic and Modern Medicine | 261 |
28 | The Human Genome Project | 265 |
29 | The Medical-Genetic Synthesis and Society | 275 |
30 | A Basis for Medical Education | 284 |
Notes | 291 | |
Index | 317 |
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