Genes and Common Diseases: Genetics in Modern Medicine Book

Part I. Introductory Principles:

1. Genes and their expression Dirk-Jan Kleinjan;
2. Epigenetic modification of chromatin Donncha Dunican, Sari Pennings and Richard Meehan;
3. Population genetics and disease Donald Conrad and Jonathan Pritchard;
4. Mapping common disease genes Naomi Wray and Petter Visscher;
5. Population diversity, genomes and disease Gianpiero Cavalleri and David Goldstein;
6. Study design in mapping complex disease traits Harry Campbell and Igor Rudan;
7. Diseases of protein misfolding Christopher Dobson;
8. Aging and disease Thomas Perls;
9. The MHC paradigm - genetic variation and complex disease Adrian Kelly and John Trowsdale;
10. Lessons from single gene disorders Nicholas Hastie;
11. Environment and disease A. J. McMichael and K. B. G. Dear;
12. Contemporary ethico-legal issues in genetics Renate Gertz, Shawn Harmon and Geoffrey Pradella;

Part II. Common Medical Disorders:
13. Developmental disorders Stephen Robertson and Andrew Wilkie;
14. Genes, environment and cancer Timothy Bishop;
15. The polygenic basis of breast cancer Paul Pharoah and Bruce Ponder;
16. TP53: a master gene in normal and tumour suppression Pierre Hainaut;
17. Genetics of colorectal cancer Susan Farrington and Malcolm Dunlop;
18. Genetics of autoimmune disease John Bell and Lars Fugger;
19. Susceptibility to infectious diseases Andrew Walley and Adrian Hill;
20. Inflammatory bowel diseases Jean-Pierre Hugot;
21. Genetic anaemias W. G. Wood and D. R. Higgs;
22. Genetics of chronic disease: obesity Sadaf Farooqi and Stephen O'Rahilly;
23. Type 2 diabetes mellitus Mark McCarthy;
24. Genetics of coronary heart disease Rossi Naoumova, Stuart Cook, Paul Cook and Timothy Aitman;
25. Genetics of hypertension B. Keavney and M. Lathrop;
26. Obstructive pulmonary disease Bipen Patel and David Lomas;
27. Skeletal disorders Robert Colbert;
28. The genetics of common skin diseases Jonathan Rees;
29. Molecular genetics of Alzheimer disease and other adult-onset dementias Peter St George-Hyslop;
30. Major psychiatric disorders in adult life Amanda Elkin, Sridevi Kalidindi, Kopal Tandon and Peter McGuffin;
31. Speech and language disorders Gabrielle Barnby and Anthony Monaco;
32. Common forms of visual handicap Alan Wright;
33. Genetic and environmental influences on hearing impairment Karen Steel;
34. Pharmacogenomics - clinical applications Gillian Smith and Roland Wolf.