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Contributors vii
Preface xi
1 The Immunology of Gene Transfer: An Overview Braden Waters, B.S. David Lillicrap, M.D. 1
2 Innate Immune Responses to Nucleic Acids Ken J. Ishii, M.D., Ph.D. Shohei Koyama, M.D. Shizuo Akira, M.D., Ph.D. 19
3 The Antiviral Innate Immune Response Mark E. Seamone, B.S. Daniel A. Muruve, M.D. 35
4 Immune Responses to Adenoviral Vectors Nelson C. Di Paolo, Ph.D. Dmitry M. Shayakhmetov, Ph.D. 57
5 Immune Response to Lentiviral Vectors Lung-Ji Chang, Ph.D. 85
6 Immune Responses to Adeno-Associated Virus Vectors Shih-Wen Lin, Ph.D. Hildegund Ertl, M.D. 97
7 Immune Responses After In Utero and Neonatal Gene Transfer Simon N. Waddington, Ph.D. Suzanne M. K. Buckley, Ph.D. Megha S. Nivsarkar, Ph.D. Charles Coutelle, M.D., Ph.D. 125
8 Immunology of Hepatic Gene Transfer Brad E. Hoffman, Ph.D. Roland W. Herzog, Ph.D. 143
9 Immune Responses to Adenoviral, Adeno-Associated Viral, and Lentiviral Vectors Used for Gene Therapy of Brain Diseases Pedro R. Lowenstein, M.D., Ph.D. Ronald J. Mandel, Ph.D. Wei-Dong Xiong, M.D., Ph.D. Kurt Kroeger, M.S. Maria G. Castro, Ph.D. 167
10 Immunology of Cutaneous Gene Transfer Soosan Ghazizadeh, Ph.D. 199
11 Immune Responses to Pulmonary Gene Therapy Christian Muller, Ph.D. Terence R. Flotte, M.D. 221
12 Induction of Immune Tolerance Through Gene Transfer to Hematopoietic Stem Cells Jessamyn Bagley, Ph.D. Chaorui Tian, M.D. John Iacomini, Ph.D. 243
13 Reconstitution of the Immune System by Gene Therapy Waseem Qasim, M.D., Ph.D. Adrian Thrasher, M.D., Ph.D. 267
14 Genetics of the Immune Response to Proteins Expressed After Gene Transfer Jay Lozier, M.D., Ph.D. 289
15 Immune Modulation and TransientSuppression Strategies Valder R. Arruda, M.D., Ph.D. 311
16 Gene Therapy for Autoimmune Diseases Massimo M. Trucco, M.D. Paul D. Robbins, Ph.D. Nick Giannoukakis, Ph.D. 331
17 Engineering of Viral Capsids to Evade the Host Immune System Luca Perabo, Ph.D. Jorge Boucas, M.S. Oliver Coutelle, M.D., Ph.D. Michael Hallek, M.D. Hildegard Buning, Ph.D. 363
Index 379
| Price | Condition | Delivery | Seller | Action |
| $121.05 | Digital |
| WonderClub |
Jozef Dekan
reviewed Gene Therapy Immunology on August 20, 2017
Gene Therapy Immunology
The book opens with the mass poisoning of thousands of people in Bangladesh by drinking water contaminated with arsenic. This book has a very important current environmental message for all of us because environmental arsenic is not just a problem facing Bangladesh. There is a USGS map on page 161 showing the states in the U.S. where acquifers used for drinking water contain dangerously high levels of arsenic. As a cancer patient, I have often wondered why I keep meeting people who are being treated for cancer but are in none of the high-risk groups. I was surprised to read in this book that years of exposure to water contaminated with non-lethal levels of arsenic causes lung cancer. Unfortunately, this surprising information is floating around in a hodge-podge of history and unrelated anecdotes.
I would have assumed that a major publishing company like Macmillan still employed editors in 2005 but, apparently, I was wrong. The author is obviously extremely knowledgeable, and the separate topics he addresses are all interesting but the book is totally disjointed.
I imagine that the author wrote a long academic article addressing the arsenic contaminated well water in Bangladesh, a medium length exposé on the history and ethics of William Morris & Company. Someone remarked "You have almost enough material for a book." The author tossed in a short popular article on the worldwide problem of environmental arsenic, and several short sensational anecdotes about murders committed using arsenic and mailed the separate articles to Macmillan. His publisher dropped the articles on the floor, told an intern to put them back in order and then published them.
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