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Endocrine Therapy for Breast Cancer Book

Endocrine Therapy for Breast Cancer
Endocrine Therapy for Breast Cancer, Because of the predominant role estrogens play in the development of breast cancer and the limited effectiveness of tamoxifen therapy, more selective therapeutics targeting estrogen signaling have been developed: selective estrogen receptor modulators (SE, Endocrine Therapy for Breast Cancer has a rating of 3 stars
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Endocrine Therapy for Breast Cancer, Because of the predominant role estrogens play in the development of breast cancer and the limited effectiveness of tamoxifen therapy, more selective therapeutics targeting estrogen signaling have been developed: selective estrogen receptor modulators (SE, Endocrine Therapy for Breast Cancer
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  • Endocrine Therapy for Breast Cancer
  • Written by author James N. Ingle
  • Published by Informa Healthcare, July 2004
  • Because of the predominant role estrogens play in the development of breast cancer and the limited effectiveness of tamoxifen therapy, more selective therapeutics targeting estrogen signaling have been developed: selective estrogen receptor modulators (SE
  • Because of the predominant role estrogens play in the development of breast cancer and the limited effectiveness of tamoxifen therapy, more selective therapeutics targeting estrogen signaling have been developed: selective estrogen receptor modulators
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Preface
Chapter 1Clinical Pharmacology of SERMs and Pure Anti-estrogens1
Chapter 2Aromatase Inhibitors: The Third Generation17
Chapter 3Systemic Therapy of Metastatic Breast Cancer in Postmenopausal Patients13
Chapter 4ATAC: Early Breast Cancer47
Chapter 5Aromatase Inhibitors and Other Agents in Early-Stage Breast Cancer55
Chapter 6Neoadjuvant Therapy in Postmenopausal Women73
Panel Discussion 1Therapy in Postmenopausal Women87
Chapter 7Endocrine Therapy for Advanced Breast Cancer in Premenopausal Women105
Chapter 8Adjuvant Endocrine Treatment in Premenopausal Patients115
Chapter 9Adjuvant Chemotherapy in Breast Cancer Patients with Hormone-Receptor-Positive (Responsive) Disease: Focus on Premenopausal Women127
Panel Discussion 2Therapy in Premenopausal Women137
Chapter 10Biology of Premalignant Lesions and Pathogenesis153
Chapter 11Estradiol-Induced Carcinogenesis via Formation of Genotoxic Metabolites
Chapter 12Beyond Tamoxifen: Results of Clinical Trials179
Chapter 13Clinical Trials with Aromatase Inhibitors for the Prevention of Breast Cancer189
Panel Discussion 3Chemoprevention203
Chapter 14Crosstalk Between Estrogen-Receptor and Growth-Factor-Receptor Pathways as a Mechanism of Endocrine Therapy Resistance215
Chapter 15ErbB2/HER-2 and Other Molecular Pathways in Estrogen-Receptor-Positive Breast Cancer: Impact on Endocrine Resistance and Clinical Outcome229
Chapter 16Beyond Antihormones in the Targeted Therapy of Breast Cancer
Chapter 17Novel Therapeutics259
Chapter 18Surrogate Biomarkers and Neoadjuvant Endocrine Therapy269
Chapter 19Aromatase Localization in Human Breast Cancer with Development of New Antibodies
Panel Discussion 4Biology and New Therapeutics287
Panel Discussion 5Final Discussion and Wrap-up295
Index311


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