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Preface | v | |
Part I | Synthesis and Properties of Bioactive Compounds | |
Design, Synthesis and Biological Evaluation of Cyclic Angiotensin II Analogues with 3,5 Side-Chain Bridges: Role of C-Terminal Aromatic Residue and Positions 3,5 for Activity | 3 | |
Synthesis of RGD Analogs Incorporating Moiety of Salicylic Acid Derivatives and their Effect on Human Platelet Aggregation In Vitro | 13 | |
Synthesis of Substance P C-terminal Analogs Incorporating D-Amino Acids and Studies of their Antineoplastic Properties in Vitro | 20 | |
Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N-protected [alpha]-Amino Acids as Precursors. Structural Characterization of Tetramic Acid Complexes with Metal Ions | 25 | |
L-Asparaginase: Structure, Properties and Anti-Tumor Activity | 33 | |
Growth Inhibitory and Apoptotic Effects of Gonadotropin-Releasing Hormone (GnRH) on Human Hepatocellular Carcinoma | 41 | |
Recent Applications of the Amide Approach to the Synthesis of Medicinally Interesting Polyamine Analogues | 53 | |
Design and Synthesis of Fluorescent Steroidal Lipopolyamine Conjugates for Monitoring Gene Delivery | 64 | |
Synthesis of (S)-2-Amino-oleic Acid and Other Bioactive Molecules through Glutamate Semialdehydes | 76 | |
Development of New Methods for Fluorometric Assays of Enzymes | 83 | |
Enhancement of the Cytogenetic and Cytostatic Activity of Chlorambucil after its Esteric Connection with a Hecogenin Lactam | 97 | |
In Searching for New Anti-Influenza A Drugs: Heterocyclic and Carbocyclic Aminoadamantanes Bearing a 2-Adamantyl Group with Potent Activity Against Influenza A Virus | 103 | |
Design, Synthesis and Conformational Properties of Linear Analogues of Human Myelin Basic Protein Epitope MBP[subscript 1-11] | 116 | |
Part II | Role of Membranes in Drug Activity | |
The Effects of Vinblastine Sulfate on Dipalmitoylphosphatidylcholine Single and Multiple Bilayer Membranes | 125 | |
Stealth Liposomal Vinca Alkaloids (Vinorelbine and Vincrastine) and In Vitro Studies on Release by Buffer and Rat Plasma | 131 | |
Structural Elucidation, Conformational Properties and Effects in Membrane Bilayers of the Toxin Paralysin, [beta]-Ala-Tyr from Larvae of the Gray Flesh Fly | 142 | |
Effects of NSAIDs in Membrane Bilayers | 150 | |
Part III | Conformational Analysis of Bioactive Compounds | |
The Structure of Endotoxin-Neutralizing Peptides Bound to LPS | 161 | |
Synthesis and Conformational Analysis of Steroidal Carriers of Alkylating Agents with the Use of Two-Dimensional Nuclear Magnetic Resonance | 167 | |
Structure Elucidation and Conformational Properties of Irbesartan | 174 | |
[superscript 1]H and [superscript 13]C NMR Assignment and Conformational Studies of a Myelin Basic Protein Epitope 74-85 Implicated in Multiple Sclerosis | 180 | |
Conformational Analysis of Biomolecules in Solution: NMR--3D Structures--Biological Implications | 188 | |
Synthesis and Structural Investigation of a Synthetic LHRH Analogue in Solution | 205 | |
Synthesis, Biological Evaluation & NMR Solution Structural Models of New Oxytocin Analogues | 217 | |
Part IV | Molecular Targets and Drug Design | |
Molecular Aspects of Human Abdominal Aortic Aneurysm: Differential Expression of Genes Coding for Extracellular Matrix Proteoglycans | 229 | |
Advances in Botulinum Neurotoxin Inhibitors Based on the SNARE Motif | 236 | |
Effect of Linear and Cyclic Peptide Analogues of Myelin Basic Protein Epitope MBP[subscript 72-85] on Human T-cell Activation | 241 | |
Use of Synthetic Peptides for the Identification of the Biologically Active Domains of the Growth Factor HARP | 251 | |
Unusual Interactions between MHC, Peptide and the T cell Receptor | 258 | |
Effects of Angiotensin II, III and IV on Memory Retention of Rats: Interaction with Adenosine A[subscript 1] Receptor Related Ligands | 267 | |
Molecular Targets and Compounds for Anti-HIV Therapy | 272 | |
Proteomics in Drug Discovery: Potential and Limitations | 279 | |
Evaluation of Tumor Capabilities for Recurrence in Patients with Larynx and Pharynx Malignancies on the Basis of DNA Criterion | 294 | |
Significance of G-protein-coupled Receptor Polymorphisms: The Case of [alpha subscript 2]-adrenergic Receptor | 299 | |
Computer Graphics Applications on Molecular Biology and Drug Design | 305 | |
Investigation of Novel DNA Gyrase Inhibitors Using the High Resolution NMR Spectroscopy | 312 | |
Author Index | 323 |
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