Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management Book

Part I. The Molecular, Cellular and Genetic Basis of Hemoglobin Disorders:

1. A developmental approach to hematopoiesis Elaine Dzierzak;
2. Erythropoiesis S. Philipsen and W. G. Wood;
3. The normal structure and regulation of human globin gene clusters Bernard G. Forget and Ross C. Hardison;
4. Nuclear factors that regulate erythropoiesis Gerd A. Blobel and Mitchell J. Weiss;
5. Molecular and cellular basis of hemoglobin switching George Stamatoyannopoulos, Patrick A. Navas, and Qiliang Li;
6. Structure and function of hemoglobin and its dysfunction in sickle cell disease Daniel Kim-Shapiro;
7. Hemoglobins of the embryo, fetus and adult Martin H. Steinberg and Ronald L. Nagel;

Part II. No Title Yet:
8. Missing chapter;
9. Missing chapter;
10. The biology of vascular nitric oxide Jane A. Leopold and Joseph Loscalzo;
11. Mechanisms and clinical complications of hemolysis in sickle cell disease and thalassemia Gregory J. Kato and Mark T. Gladwin;
12. Missing chapter;

Part III. α Thalassemia:
13. The molecular basis of alpha thalassemia D.R. Higgs;
14. The pathophysiology and clinical features of alpha thalassaemia Douglas R. Higgs;
15. Unusual types of alpha thalassaemia Douglas R. Higgs, Veronica Buckle, Richard Gibbons, and David Steensma;

Part IV. The β Thalassemias:
16. The molecular basis of β thalassemia, α thalassemia and HPFH S. L. Thein and W. G. Wood;
17. Clinical aspects of β thalassemia and related disorders Nancy F. Olivieri, D. K. Bowden, and D. J. Weatherall;
18. Hemoglobin E disorders Suthat Fucharoen and David Weatherall;

Part V. SickleCell Disease:
19. Clinical and pathophysiological aspects of sickle cell anemia Martin Steinberg, Kwaku Ohene-Frempong, and Matthew M. Heeney;
20. Sickle cell pain: biology; etiology; treatment Samir K. Ballas and James R. Eckman;
21. Hemoglobin SC disease and HbC disorders Martin H. Steinberg and Ronald L. Nagel;
22. Sickle cell trait Martin H. Steinberg;
23. Other sickle hemoglobinopathies Martin H. Steinberg;

Part VI. Other Clinically Important Disorders of Hemoglobin:
24. Unstable hemoglobins; hemoglobins with altered oxygen affinity; hemoglobin M; other variants of clinical and biological interest Martin H. Steinberg and Ronald L. Nagel;
25. Dyshemoglobinemias Neeraj Agarwal, Ronald L. Nagel, and Josef T. Prchal;

Part VII. Special Topics in Hemoglobinopathies:
26. Population genetics and global health burden David J. Weatherall and Thomas N. Williams;
27. Genetic modulation of sickle cell disease and thalassemia Martin H. Steinberg and Ronald L. Nagel;
28. Laboratory methods for diagnosis and evaluation of hemoglobin disorders Mary Fabry and John M. Old;

Part VIII. No Title Yet:
29. Missing chapter;
30. Induction of fetal hemoglobin in the treatment of sickle cell disease and β thalassemia Yogen Saunthararajah and George F. Atweh;
31. Missing chapter;
32. Stem cell transplantation Emanuele Angelucci and Mark Walters;
33. Prospects for gene therapy of sickle cell disease and thalassemia Derek A. Persons, Brian P. Sorrentino, and Arthur W. Nienhuis.