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Contributors ix
Foreword xiii
Preface xv
1 Biocatalytic Methodologies for Selective Modified Nucleosides 1
Miguel Ferrero, Susana Fern´andez, and Vicente Gotor
2 Nucleosides Modified at the Base Moiety 49
O. Sari, V. Roy, and L. A. Agrofoglio
3 Chemical Synthesis of Acyclic Nucleosides 103
Hai-Ming Guo, Shan Wu, Hong-Ying Niu, Ge Song, and Gui-Rong Qu
4 Phosphonated Nucleoside Analogues 163
Roberto Romeo, Caterina Carnovale, Antonio Rescifina, and Maria Assunta Chiacchio
5 Chemical Syntheses of Nucleoside Triphosphates 209
Lina Weinschenk and Chris Meier
6 Mononucleotide Prodrug Synthetic Strategies 229
Suzanne Peyrottes and Christian P´erigaud
7 Synthesis of C-Nucleosides 263
Omar Boutureira, M. Isabel Matheu, Yolanda D´yaz, and Sergio Castill´on
8 Methodologies for the Synthesis of Isomeric Nucleosides and Nucleotides of Antiviral Significance 317
Maurice Okello and Vasu Nair
9 Synthesis of Conformationally Constrained Nucleoside Analogues 345
Esma Maougal, Jean-Marc Escudier, Christophe Len, Didier Dubreuil, and Jacques Lebreton
10 Synthesis of 3-Spiro-Substituted Nucleosides: Chemistry of TSAO Nucleoside Derivatives 427
Mar´ya-Jos´e Camarasa, Sonsoles Vel´azquez, Ana San-F´elix, and Mar´ya-Jes´us P´erez-P´erez
11 l-Nucleosides 473
Daniela Perrone and Massimo L. Capobianco
12 Chemical Synthesis of Carbocyclic Analogues of Nucleosides 535
E. Leclerc
13 Uncommon Three-, Four-, and Six-Membered Nucleosides 605
E. Groaz and P. Herdewijn
14 Recent Advances in Synthesis and Biological Activity of 4-Thionucleosides 655
Varughese A. Mulamoottil, Mahesh S. Majik, Girish Chandra, and Lak Shin Jeong
15 Recent Advances in the Chemical Synthesis of Aza-Nucleosides 699
Tom´as Tejero, Ignacio Delso, and Pedro Merino
16 Stereoselective Methods in the Synthesis of Bioactive Oxathiolane and Dioxolane Nucleosides 727
D. D’Alonzo and A. Guaragna
17 Isoxazolidinyl Nucleosides 781
Ugo Chiacchio, Antonino Corsaro, Salvatore Giof&rgrave;e, and Giovanni Romeo
18 Synthetic Studies on Antifungal Peptidyl Nucleoside Antibiotics 819
Apurba Datta
19 Chemical Synthesis of Conformationally Constrained PNA Monomers 847
Pedro Merino and Rosa Matute
Index 881
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