Cardiac Electrophysiology: From Cell to Bedside: Expert Consult - Online and Print Book

	Color plates
Ch. 1	Sodium channels	1
Ch. 2	Cardiac calcium channels	10
Ch. 3	Voltage-regulated potassium channels	19
Ch. 4	Intracellular signaling and regulation of cardiac ion channels	33
Ch. 5	Membrane pumps and exchangers	42
Ch. 6	Sarcoplasmic reticulum ion channels	51
Ch. 7	HCN channels : from genes to function	59
Ch. 8	Molecular organization and regulation of the cardiac gap junction channel Connexin43	66
Ch. 9	Biophysics of normal and abnormal cardiac sodium channel function	77
Ch. 10	Gating of cardiac delayed rectifier K[superscript +] channels	88
Ch. 11	Heart mechanoelectric transduction	96
Ch. 12	Pacemaker channels and normal automaticity	103
Ch. 13	Biophysical properties of inward rectifier potassium channels	112
Ch. 14	Homomeric and heteromeric gap junctions	120
Ch. 15	Pharmacology of the cardiac sodium channel	127
Ch. 16	Pharmacology of the L-type and T-type channels in the heart	133
Ch. 17	KCNQ1/KCNE1 macromolecular signaling complex : channel microdomains and human disease	143
Ch. 18	Drug-induced channelopathies	151
Ch. 19	Prospects for pharmacologic targeting of gap junction channels	158
Ch. 20	Heterogeneous expression of potassium channels in the mammalian myocardium	169
Ch. 21	Gap junction distribution and regulation in the heart	181
Ch. 22	Cellular mechanisms of sinoatrial activity	192
Ch. 23	Mechanisms of AV nodal excitability and propagation	203
Ch. 24	Intercellular communication and impulse propagation	213
Ch. 25	Cardiac tissue architecture determines velocity and safety of propagation	222
Ch. 26	Restitution, repolarization, and alternans as arrhythmogenic substrates	232
Ch. 27	Mechanoelectric transduction/feedback : prevalence and pathophysiology	242
Ch. 28	Ionic mechanisms of cardiac electrical activity : a theoretical approach	255
Ch. 29	Two-dimensional propagation in cardiac muscle	267
Ch. 30	Three-dimensional propagation in mathematical models : integrative model of the mouse heart	273
Ch. 31	Modeling cardiac defibrillation	282
Ch. 32	Molecular and cellular bases of [beta]-adrenergic and [alpha]-adrenergic modulation of cardiac rhythm	291
Ch. 33	Nerve sprouting and cardiac arrhythmias	299
Ch. 34	Cholinergic atrial fibrillation	306
Ch. 35	Theory of reentry	317
Ch. 36	Nonlinear dynamics of excitation and propagation in cardiac muscle	327
Ch. 37	Rotors and spiral waves in two dimensions	336
Ch. 38	Scroll waves in three dimensions	345
Ch. 39	Electrophysiology of the pulmonary veins : mechanisms of initiation of atrial fibrillation	355
Ch. 40	Mechanisms of maintenance of atrial fibrillation	363
Ch. 41	Electrical remodeling and chronic atrial fibrillation	375
Ch. 42	Mechanisms of initiation of ventricular tachyarrhythmias	380
Ch. 43	Dynamics and molecular mechanisms of ventricular fibrillation in normal hearts	390
Ch. 44	Mechanisms of ischemic ventricular fibrillation : who's the killer?	399
Ch. 45	Cellular mechanisms of defibrillation	407
Ch. 46	Global mechanisms of defibrillation	417
Ch. 47	Defibrillation waveforms	426
Ch. 48	Mouse models of cardiac arrhythmias	433
Ch. 49	Human molecular genetics and the heart	444
Ch. 50	Genetics of long QT, Brugada, and other channelopathies	462
Ch. 51	Pharmacogenomics of cardiac arrhythmias and impact on drug therapy	471
Ch. 52	Sinus rhythm abnormalities	479
Ch. 53	Atrioventricular block and atrioventricular dissociation	485
Ch. 54	Atrial flutter : mechanisms, clinical features, and management	490
Ch. 55	Atrial tachycardia	500
Ch. 56	Atrial fibrillation	512
Ch. 57	Junctional rhythms and junctional tachycardia	523
Ch. 58	Atrioventricular reentry and variants	528
Ch. 59	Electrophysiologic characteristics of atrioventricular nodal reentrant tachycardia : implications for the reentrant circuits
Ch. 60	Atrial arrhythmias in congenital heart disease	558
Ch. 61	Ventricular tachycardia in patients with coronary artery disease	569
Ch. 62	Ventricular tachycardia in patients with dilated cardiomyopathy	575
Ch. 63	Ventricular tachycardia in arrhythmogenic right ventricular cardiomyopathies	588
Ch. 64	Ventricular arrhythmias in hypertrophic cardiomyopathy	601
Ch. 65	Ventricular tachycardia in patients with hypertrophy and heart failure	608
Ch. 66	Ventricular tachycardia in patients following surgery for congenital heart disease	618
Ch. 67	The Brugada syndrome	625
Ch. 68	Catecholaminergic polymorphic ventricular tachycardia and short-coupled torsades de pointes	633
Ch. 69	Arrythmias in patients with neurologic disorders	640
Ch. 70	Long QT syndrome - genotype-phenotype considerations	651
Ch. 71	Long QT syndrome : therapeutic considerations	660
Ch. 72	Ventricular tachycardia in patients with structurally normal hearts	668
Ch. 73	Bundle branch reentry	683
Ch. 74	Torsade de pointes	687
Ch. 75	Accelerated idioventricular rhythm and bidirectional ventricular tachycardia	700
Ch. 76	Ventricular fibrillation	705
Ch. 77	Prolonged repolarization and sudden infant death syndrome	711
Ch. 78	Sudden cardiac death	720
Ch. 79	Electrocardiographic manifestations of supernormal conduction, concealed conduction, and exit block	733
Ch. 80	Parasystole	739
Ch. 81	Differential diagnosis of wide QRS complex tachycardia	747
Ch. 82	Assessment of the patient with a cardiac arrhythmia	759
Ch. 83	Exercise-induced cardiac arrhythmias	765
Ch. 84	Use of long-term (holter) electrocardiographic recordings	772
Ch. 85	The use of implantable loop recorders	793
Ch. 86	High-resolution electrocardiography	793
Ch. 87	Body surface potential mapping	803
Ch. 88	Head-up tilt table testing	812
Ch. 89	Heart rate variability and baroreflex sensitivity	823
Ch. 90	Monophasic action potential recording	831
Ch. 91	T-wave alternans	839
Ch. 92	Neurocardiac imaging	848
Ch. 93	Mapping	858
Ch. 94	Wolff-Parkinson-White syndrome	869
Ch. 95	Sinus node dysfunction	879
Ch. 96	Syncope	884
Ch. 97	Results of clinical trials on atrial fibrillation	895
Ch. 98	Results of clinical trails of automatic external defibrillators and implantable cardioverter-defibrillators in patients at risk for sudden death	901
Ch. 99	Class I antiarrhythmic drugs : quinidine, procainamide, disopyramide, lidocaine, mexiletine, flecainide and propafenone	911
Ch. 100	[beta]-blockers and calcium channel blockers as antiarrhythmic drugs	918
Ch. 101	Class III antiarrhythmic drugs : amiodarone, ibutilide, and sotalol	932
Ch. 102	Adenosine and digoxin	942
Ch. 103	Impact of nontraditional antiarrhythmic drugs on sudden cardiac death	950
Ch. 104	New antiarrhythmic drugs	959
Ch. 105	Transthoracic cardioversion and defibrillation	966
Ch. 106	Implantable cardioverter-defibrillator : technical aspects	970
Ch. 107	Implantable cardioverter-defibrillators : clinical aspects	980
Ch. 108	Implantable atrial defibrillators for atrial fibrillation	995
Ch. 109	Implantable pacemakers	1000
Ch. 110	Newer applications of pacemakers	1011
Ch. 111	The biophysics and pathophysiology of lesion formation during radiofrequency catheter ablation	1018
Ch. 112	Catheter ablation of atrial fibrillation : triggers and substrate	1028
Ch. 113	Pulmonary vein isolation for atrial fibrillation	1039
Ch. 114	Catheter ablation of atrial flutter	1053
Ch. 115	Catheter ablation of atrial tachycardia	1060