Cancer Chemoprevention: Volume 1: Promising Cancer Chemopreventive Agents Book

Part I. Antimutagens

Inducers of Enzymes That Protect Against Carcinogens and Oxidants: Drug- and Food-Based Approaches with Dithiolethiones and Sulforaphane

Thomas W. Kensler and Paul Talalay

Chemoprevention by Isothiocyanates

Stephen S. Hecht

Antigenotoxic and Cancer Preventive Mechanisms of N-Acetyl-l-Cysteine

Silvio De Flora, Alberto Izzotti, Adriana Albini, Francesco D'Agostini, Maria Bagnasco, and Roumen Balansky

Modifiers of Cyhrome(s) P450

John DiGiovanni and Heather E. Kleiner

Part II. Antiinflammatories

Antiinflammatories and Chemoprevention: NSAIDs and Other Inhibitors of Arachidonic Acid Metabolism

Gary B. Gordon, Gary J. Kelloff, and Caroline C. Sigman

Cyclooxygenase-2 Inhibitors and Colorectal Cancer Prevention

Raymond N. DuBois

Lipoxygenases as Targets for Cancer Prevention

Susan M. Fischer and Russell D. Klein

Inducible Nitric Oxide Synthase as a Target for Chemoprevention

Lorne J. Hofseth, Tomohiro Sawa, S. Perwez Hussain, and Curtis C. Harris

Chemoprevention of Cancer of the Respiratory Tract by Agents Delivered by Aerosol: Applications to Glucocorticoids and 5-Fluorouracil

Timothy S. Wiedmann and Lee W. Wattenberg

Chemoprevention of Cancer by Curcumin

Bandaru S. Reddy and Chinthalapally V. Rao

Prostacyclin and Lung Cancer Chemoprevention

Robert L. Keith, York E. Miller, Paul A. Bunn Jr., Patrick Nana-Sinkam, Raphael A. Nemenoff, and Mark W. Geraci

Part III. Nuclear Receptor Superfamily

Nuclear Receptor Superfamily: Targets for Chemoprevention

Julia A. Lawrence and Kapil Dhingra

A. Antiandrogens

Prostate Cancer Chemoprevention: 5a-Reductase Inhibitors

Jennifer E. Drisko and Siu-Long Yao

Searching for SARA: The Role of Selective Androgen-Receptor Antagonists in Prostate Cancer

Mark S. Chapman, William Y. Chang, Andr&e's Negro-Vilar, and Jeffrey N. Miner

B. Antiestrogens

Aromatase Inhibitors as Chemopreventives of Breast Cancer

Mitchell Dowsett and Judy E. Garber

Breast Cancer Chemoprevention by Selective Estrogen Receptor Modulators

Carolyn L. Smith

C. Natural Vitamin D and Synthetic Analogs

Chemopreventive Efficacy of Natural Vitamin D and Synthetic Analogs

Kathryn Z. Guyton, Thomas W. Kensler, and Gary H. Posner

D. Retinoids

The Retinoids and Cancer Chemoprevention

Sutisak Kitareewan, Ian Pitha-Rowe, Yan Ma, Sarah J. Freemantle, and Ethan Dmitrovsky

E. Dehydroepiandrosterone and Structural Analogs

Biologic and Therapeutic Effects of Dehydroepiandrosterone and Structural Analogs

Arthur G. Schwartz and Laura L. Pashko

Part IV. Signal Transduction Modulators

ras Oncogene Inhibitors

Nancy E. Kohl

The Potential of EGFR-Targeted Agents in Cancer Prevention

Steven D. Averbuch and Fadlo R. Khuri

Pharmacological Intervention with Multistep Oncogenesis: Potential Role for HSP90 Molecular Chaperone Inhibitors

Paul Workman

Therapeutic Strategies Targeting Polyamines

Debora L. Kramer and Eugene W. Gerner

The Role of Phytoestrogens as Cancer Prevention Agents

Stephen Barnes and Coral A. Lamartiniere

Cancer Chemopreventive Activity of Monoterpenes and Other Isoprenoids

Pamela L. Crowell and Michael N. Gould

Development of an Inhibitor of raf Kinase

Frank McCormick

Abnormalities in Cell Cycle Control in Human Cancer and Their Relevance to Chemoprevention

Alessandro Sgambato and I. Bernard Weinstein

Select Cyclic Nucleotide Phosphodiesterase Inhibitors in Colon Tumor Chemoprevention and Chemotherapy

Melissa K. Reeder, Rifat Pamakcu, I. Bernard Weinstein, Kirk Hoffman, and W. Joseph Thompson

Part V. Antioxidants, Vitamins, and Minerals

Chemoprevention by Fruit Phenolic Compounds

Gary D. Stoner and Bruce C. Casto

Tea Polyphenols as Cancer Chemopreventive Agents

Vaqar M. Adhami, Farrukh Afaq, Nihal Ahmad, Yukihiko Hara, and Hasan Mukhtar

Vitamin E as a Cancer Chemopreventive Agent

Han-Yao Huang, Sonja Berndt, and Kathy J. Helzlsouer

Vitamin C as a Cancer Chemopreventive Agent

Jane Higdon and Balz Frei

Carotenoids

Susan T. Mayne and Brenda Cartmel

Lycopene, a Dietary Cancer Chemopreventive Agent

Andreas I. Constantinou and Richard B. van Breemen

Not All Chemopreventive Selenium Compounds are Created Equal

Karam El-Bayoumy

Calcium

John A. Baron

Folate and Cancer Chemoprevention

Shumin M. Zhang and Walter C. Willett

Conjugated Linoleic Acid as a Tumor Preventive Agent

David Kritchevsky and Michael W. Pariza

Chemopreventive Effects of Omega-3 Fatty Acids

Joanne R. Lupton and Robert S. Chapkin

Part VI. Agents Targeting Biological Processes Important in Cancer

Tumor Angiogenesis as a Target for Early Intervention and Cancer Prevention

William W. Li

Proteasome Inhibitors in Cancer Therapy

Julian Adams

Modulation of DNA Methylation for the Treatment and Prevention of Cancer

David S. Schrump

Targeting Histone Deacetylase as a Strategy for Cancer Prevention

Ho Jung Oh, Eun Joo Chung, Sunmin Lee, Andrea Loaiza-Perez, Edward A. Sausville, and Jane B. Trepel

Index