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Blood - Spinal Cord and Brain Barriers in Health and Science Book

Blood - Spinal Cord and Brain Barriers in Health and Science
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  • Blood - Spinal Cord and Brain Barriers in Health and Science
  • Written by author Hari Shanker Sharma
  • Published by Elsevier Science, November 2003
  • Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings i
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Authors

Contributors
Foreword
Introduction
Preface
Acknowledgments
Sect. IBasic Aspects: Structure and Functions of Cerebrovascular Barriers
1Proteins of the Tight Junction in the Blood-Brain Barrier1
2Direct Demonstration of Association of the Blood-Brain Barrier Proteins ZO-1 and Occludin Using Surface Plasmon Resonance Spectroscopy; Effect of SIN-111
3Investigation of Molecular Mechanisms Involved in T Lymphocyte Recruitment across the Blood-Spinal Cord and Brain Barriers in Health and Disease19
Sect. IITechnical and Functional Aspects: Cerebrovascular Barriers in Vitro
4Transport and Permeability Characteristics of the Blood - Cerebrospinal Fluid Barrier in Vitro33
5Brain Microvessel Endothelial Cell Cultures as in Vitro Models to Study the Blood-Brain Barrier47
Sect. IIIPhysiological Aspects: Transport Mechanisms Across Cerebrovascular Barriers
6Brain Influx of Endogenous Peptides Affecting Food Intake57
7Implications of P-glycoprotein for the Transport and Distribution of Drugs into the Brain63
8Role of the Blood-Brain Barrier in Communication between the Central Nervous System and the Peripheral Tissues73
9Efflux Mechanisms in the Central Nervous System: A Powerful Influence on Drug Distribution within the Brain83
10Mechanisms of Antisense Transport across the Blood-Brain Barrier99
11Peptides and the Blood-Brain Barrier: Enhancing Peptide Bioavailability to the Brain107
Sect. IVPharmacological Aspects: Neurochemical Mediators of the Cerebrovascular Barriers
12Influence of Serotonin on the Blood-Brain and the Blood-Spinal Cord Barriers117
13Histamine Influences the Blood-Spinal Cord and Brain Barriers Following Injuries to the Central Nervous System159
14Role of Nitric Oxide on the Blood-Brain and Spinal Cord Barriers191
Sect. VNeuropsychological Aspects: Cerebrovascular Barriers in Stressful Situations
15Blood-Brain and Spinal Cord Barriers in Stress231
16Blood-Central Nervous System Barriers in Morphine Dependence and Withdrawal299
17The Heat Shock Proteins and Hemeoxygenase Response in Central Nervous System Injuries329
Sect. VINeurological Aspects: Alterations of Cerebrovascular Barriers in Disease Conditions
18Volume Transmission-Mediated Protective Impact of Choroid Plexus-Cerebrospinal Fluid Growth Factors on Forebrain Ischemic Injury361
19Blood-Brain Barrier Changes in Global and Focal Cerebral Ischemia385
20Transport of Cytokines and Neurotrophins across the Blood-Brain Barrier and Their Regulation after Spinal Cord Injury395
21Mononuclear Phagocytes at the Blood-Brain Barrier in Multiple Sclerosis409
22The Blood-Brain Barrier after Traumatic Injury: Vascular and Parenchymal Interactions419
23Pathophysiology of the Blood-Spinal Cord Barrier in Traumatic Injury437
24Growth Hormone Permeability Across the Blood-Spinal Cord and Brain Barriers and Its Therapeutic Potential in Trauma to the Spinal Cord519
25Involvement and Consequences of Blood Brain Barrier Permeability After Minimal Injury in Rat Cerebral Cortex533
Sect. VIIClinical Aspects: Cerebrovascular Barriers in Clinical Conditions
26Neural Immunity and Human Immunodeficiency Virus-1-Associated Dementia547
27The Blood-Brain Barrier in the Human Glioma561
Index577


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