|
|
Sold Out
Book Categories |
Preface.
List of Contributors.
1 A Novel Field of Research: Bioorganometallic Chemistry, Origins, and Founding Principles (Gérard Jaouen, Wolfgang Beck, and Michael J. McGlinchey).
1.1 Introduction.
1.2 Organometallics and Therapy.
1.3 Toxicology and the Environment.
1.4 Bioanalytical Methods Based on Special Properties of Organometallic Complexes.
1.5 Naturally-occurring Organometallics and Synthetic Models.
1.6 Organometallic Chemistry and Aqueous Solvents.
1.7 Conclusions.
2 Ruthenium Arene Anticancer Complexes (Michael Melchart and Peter J. Sadler).
2.1 Introduction.
2.2 Metal-based Anticancer Complexes.
2.3 Chemistry of Ru Arenes.
2.4 Biological Activity.
2.5 Mechanism of Action.
2.6 Conclusions.
3 Organometallics Targeted to Specific Biological Sites: the Development of New Therapies (Gérard Jaouen, Siden Top, and Anne Vessières).
3.1 Introduction.
3.2 Overview of Previous Developments.
3.3 Metal Complex SERMs (Selective Estrogen Receptor Modulators).
3.4 The Alkyne Cobalt Carbonyl Complexes.
3.5 Ferroquine, a New Weapon in the Fight Against Malaria: the Archetypical Bioorganometallic Approach.
3.6 Other Examples of Organometallics Complexes Tested for their Biological Activities.
3.7 Conclusion.
4 Radiopharmaceuticals (Roger Alberto).
4.1 What are Radiopharmaceuticals?
4.2 Organometallic Aquo-ions.
4.3 The Prototype [99Tc(OH2)3(CO)3]+, Synthesis and Properties.
4.4 Combining [99Tc(OH2)3(CO)3]+ with Targeting Vectors.
4.5 Perspectives.
5 Conjugates of Peptides and PNA with Organometallic Complexes: Syntheses and Applications (Nils Metzler-Nolte).
5.1 Introduction.
5.2 Conjugates of Organometallics with Small Peptides.
5.3 Conjugates of Organometallics with Natural Peptides.
5.4 Conjugates of Organometallics with PNA.
5.5 Applications.
6 Labeling of Proteins with Organometallic Complexes: Strategies and Applications (Michèle Salmain).
6.1 Introduction.
6.2 Redox Probes.
6.3 Luminescent Probes.
6.4 Heavy Metal Probes.
6.5 Metallo–carbonyl Probes for Infrared Spectroscopy.
6.6 Conclusions and Outlook.
7 Organometallic Bioprobes (G. Richard Stephenson).
7.1 Introduction.
7.2 The Definition of the Terms Bioprobes and Molecular Bioprobes.
7.3 Response Strategies for the Read-out of Information.
7.4 Organometallic Components for Organometallic Bioprobes – Opening up the Advantages of IR-based Read-out Methods.
7.5 Selectivity of Responses in IR-based Read-out Methods.
7.6 Examples of Organometalcarbonyl Bioprobe Structures.
7.7 Use of Organometallic Bioprobes with Proteins.
7.8 Power of Genetics in the Design of Bioprobe Experiments.
7.9 Conclusions.
8 Organometallic Complexes as Tracers in Non-isotopic Immunoassay (Michèle Salmain and Anne Vessières).
8.1 Introduction.
8.2 Principle of an Immunoassay.
8.3 Obtaining Specific Antibodies.
8.4 Synthesis of the Organometallic Tracers.
8.5 Examples of Mono- and Multi-metalloimmunoassays (MIA).
8.6 Use of Organometallic Complexes as Substrates or Co-substrates for Enzyme Immunoassay.
8.7 Conclusion.
9 Genosensors Based on Metal Complexes (Shigeori Takenaka).
9.1 Introduction.
9.2 Metal Complexes as DNA Probes.
9.3 Electrochemical Analysis of the Interaction of Metal Complexes with dsDNA.
9.4 Gene Detection Based on a Cationic Metal Complex or Metal Complex Conjugated with DNA-binding Ligand.
9.5 Gene Detection Based on Ferrocenyl Oligonucleotides as a Metal Complex Conjugated with DNA Fragments.
9.6 Conclusion.
10 Supramolecular Host Recognition Processes with Biological Compounds, Organometallic Pharmaceuticals, and Alkali-metal Ions as Guests (Richard H. Fish).
10.1 Introduction.
10.2 Host 1.
10.3 A New Host, trans-[Cp*Rhη1-(N3)-1-methylcytosine)(μ-OH)]2(OTf)2 2.
10.4 Computer Docking Experiments of Organometallic Pharmaceuticals at Estrogen Receptor Binding Sites: Selective, Non-Covalent Interactions with Hormone Proteins.
10.5 Organometallic Ionophores.
10.6 Overall Conclusions for Molecular Recognition.
11 Structure and Mechanism of Metalloenzyme Active Sites (Juan C. Fontecilla-Camps).
11.1 Introduction.
11.2 Copper.
11.3 Iron.
11.4 Manganese.
11.5 Molybdenum and Tungsten.
11.6 Nickel.
11.7 Zinc.
11.8 Conclusions.
12 Synthetic Models for Bioorganometallic Reaction Centers (Rachel C. Linck and Thomas B. Rauchfuss).
12.1 Introduction.
12.2 Fe-only Hydrogenase.
12.3 NiFe Hydrogenases.
12.4 Acetyl CoA Synthase.
12.5 Anaerobic Carbon Monoxide Dehydrogenase.
12.6 Aerobic Carbon Monoxide Dehydrogenase.
12.7 Methyl Coenzyme M Reductase.
12.8 Conclusions.
Subject Index.
| Price | Condition | Delivery | Seller | Action |
| $200.00 | Digital |
| WonderClub |
Katrina Whitworth
reviewed Bioorganometallics: Biomolecules, Labeling, Medicine on April 17, 2016
Bioorganometallics
FAAAASCINATING. Honestly, I kept pestering Kent, "Listen to this..." and then reading a paragraph or two. It's about the science of how the brain and body connect. We have "body maps" in our brain, that tell us exactly where our body parts are, and how they are doing. (This is why we can touch our nose with our eyes closed.) It doesn't sound interesting, until you read what this means, in practical applications. And the stuff about how our homonulcus (body maps) go awry is just astonishing.
Body mapping accounts for why we can ride a horse, why we duck a little when we drive our cars into a garage with low clearance, why we feel afraid in scary movies, and also things like autism (mirror neuron defects).
Here's an example: if you took a perfectly healthy kitten, and then carried it around with you wherever you went, exposing it to many sights and sounds, but not allowing it to interact with it's environment, that kitten would be blind. It would still "see" colors and shapes and everything, but it's brain would have no context for interpreting that input, so the cat would be just as blind as a cat with no eyes. Bizarre, huh? Here's another: the women in Mali think it's important for their children to have straight legs so several times a day, from birth onwards, they massage and pull on their infants' legs, pulling them straight. Guess the average age of walking? EIGHT MONTHS. Because those kids' body maps of their legs got so much stimulation from the environment as they were developing. Contrast that with kids in orphanages in the Eastern Block countries who are left alone in their cribs for days on end. Those kids are unable to stand on one foot without toppling over. Why? Because their leg body maps are so woefully undeveloped because there was no opportunity for interaction with their environment.
Anyhow, it's really an interesting read, runs a gamut of really diverse topics, all having to do with our body maps, and it's not very long (about 200 pages.) I really recommend it.
Login|Complaints|Blog|Games|Digital Media|Souls|Obituary|Contact Us|FAQ
CAN'T FIND WHAT YOU'RE LOOKING FOR? CLICK HERE!!! X
You must be logged in to add to WishlistX
This item is in your Wish List
X
This item is in your Collection
Bioorganometallics: Biomolecules, Labeling, Medicine
X
This Item is in Your Inventory
Bioorganometallics: Biomolecules, Labeling, Medicine
X
You must be logged in to review the productsX
X
X
Add Bioorganometallics: Biomolecules, Labeling, Medicine, , Bioorganometallics: Biomolecules, Labeling, Medicine to the inventory that you are selling on WonderClubX
X
Add Bioorganometallics: Biomolecules, Labeling, Medicine, , Bioorganometallics: Biomolecules, Labeling, Medicine to your collection on WonderClub |
