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Biomarkers and occupational health Book

Biomarkers and occupational health
Biomarkers and occupational health, Biomarkers have emerged as an exciting tool in disease prevention, particularly in the workplace. They may be used to document workers' exposure to toxins, signal the onset of health effects, or identify individuals with susceptibility to certain environm, Biomarkers and occupational health has a rating of 5 stars
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Biomarkers and occupational health, Biomarkers have emerged as an exciting tool in disease prevention, particularly in the workplace. They may be used to document workers' exposure to toxins, signal the onset of health effects, or identify individuals with susceptibility to certain environm, Biomarkers and occupational health
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  • Biomarkers and occupational health
  • Written by author National Academy of Sciences
  • Published by Washington, D.C. : Joseph Henry Press, 1995., 1995/01/16
  • Biomarkers have emerged as an exciting tool in disease prevention, particularly in the workplace. They may be used to document workers' exposure to toxins, signal the onset of health effects, or identify individuals with susceptibility to certain environm
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Introduction 1
The Current Applicability of Large Scale Biomarkers Programs to Monitor Cleanup Workers 9
Biomarkers - A Perspective from the Commission of the European Communities 20
The Role of the NIEHS in the Development of a National Program for Environmental Health Science Research 25
Legal Concerns in Worker Notification and the Use of Biomarkers in Medical Surveillance 37
Biomedical Research Ethics Related to Biomarkers 48
Biomarkers: The Down Side 52
Application of Biomarkers: Getting our Priorities Straight 61
Costs of Developing a Large-Scale Biomarker Program to Monitor Cleanup Workers 70
Biological Monitoring of Exposure to Industrial Chemicals 89
Validation of DNA Adducts as Biological Markers of Carcinogen Exposure and Effects 105
The Development, Validation, and Application of Biomarkers for Early Biologic Effects 109
The Development, Validation, and Application of Biomarkers for HIV 116
Quantitative Decision Support Systems for Surveillance and Clinical Applications 120
Medical Surveillance at a Hazardous Waste Site 133
Integrating Biomarkers into Health and Safety Programs 140
Clinical Applications of Biomarkers in Occupational Medicine 148
Mutant p21 Protein as a Biomarker of Chemical Carcinogenesis in Humans 163
Validation Studies for Monitoring of Workers Using Molecular Cytogenetics 174
Molecular Cytogenetic Approaches to the Development of Biomarkers 194
Biomarkers to Detect Radiation Exposures 215
Dioxin Congeners Distribution in Biological Samples as Biomarkers for Exposure 226
Xenobiotic-Metabolizing Enzymes in Biomarker Research 238
Implications of Large Scale DNA Analysis for the Development and Application of Biomarkers 257
Epigenetic Biomarkers: Potentials and Limitations 264
Flow Cytometry: A Powerful Technology for Measuring Biomarkers 275
A Genetic Marker for Chronic Beryllium Disease 293
Immunology of Chronic Beryllium Disease 304
Biological Monitoring of Exposure to Hexavalent Chromium in Isolated Erythrocytes 313
Contributors 325
Abbreviations 329
Index 333


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