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Table of Content
Preface
Contributors
Chapter 1 Biomarker sample collection and handling in the clinical setting to support early phase drug development
Chris B. Russell, Sid Suggs, Kristina M. Robson, Keith Kerkof, Lisa D. Kivman, Kimberly H. Notari, William A. Rees, Natalia Leshinsky, and Scott D. Patterson
Chapter 2 Gene Expression-Based Biomarkers of Drug Safety
Eric A.G. Blomme, and Scott E. Warder
Chapter 3 Profiling Gene Expression Signatures Using Fluorescent Microspheres
Suzanne M. Torontali, Jorge M. Naciff, Kenton D. Juhlin, and Jay P. Tiesman
Chapter 4 Real-Time PCR Gene Expression Assays in Biomarker Discovery and Validation
Yulei Wang, Catalin Barbacioru, David Keys, Pius Brzoska, Caifu Chen, Kelly Li, and Raymond R. Samaha
Chapter 5 SAGE Analysis in Identifying Phenotype SNPs
Sandro J. de Souza, I-Mei Siu, Janete M. Cerutti, and Gregory J. Riggins
Chapter 6 SNP and DNA Methylation Analysis using Pyrosequencing Methods
Jinsheng Yu, and Sharon Marsh
Chapter 7 The Application of LCM for the Analysis of Specific Cell-Type Gene
Expression in a Complex Tissue: the Primate Endometrium
William C. Okulicz
Chapter 8 The use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery
Brad Jarrold, Alex Varbanov, and Feng Wang
Chapter 9 Difference In Gel Electrophoresis (DIGE), a high resolution protein biomarker research tool
David S. Gibson, David Bramwell, and Caitriona Scaife
Chapter 10 Label-free Mass Spectrometry-based Protein Quantification Technologies in Protein Biomarker Discovery
Mu Wang, Jin-Sam You, Kerry G. Bemis, and Dawn P. G. Fitzpatrick
Chapter 11 Top-Down Quantitative Proteomic Analysis using a Highly Multiplexed Isobaric Mass Tagging Strategy
Bing Xie, Wayne F. Patton, and Craig E. Parman
Chapter 12 SELDI Technology for Identification of Protein Biomarkers
Prasad Devarajan, and Gary F. Ross
Chapter 13 Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High Throughput Screens
Rachel M Gonzalez, Susan M Varnum, and Richard C Zangar
Chapter 14 LC-MS Metabonomics Methodology in Biomarker Discovery
Xin Lu, and Guowang Xu
Chapter 15 GC/MS–based metabolomics
Sally-Ann Fancy, and Klaus Rumpel
Chapter16 NMR-Based Metabolomics for Biomarker Discovery
Narasimhamurthy Shanaiah, Shucha Zhang, M. Aruni Desilva, and Daniel Raftery
Chapter 17 Unraveling Glycerophospholipidomes by Lipidomics
Kim Ekroos
Index
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Add Biomarker Methods in Drug Discovery and Development, Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers , Biomarker Methods in Drug Discovery and Development to your collection on WonderClub |