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Biomarker Methods in Drug Discovery and Development Book

Biomarker Methods in Drug Discovery and Development
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Biomarker Methods in Drug Discovery and Development, Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers , Biomarker Methods in Drug Discovery and Development
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  • Biomarker Methods in Drug Discovery and Development
  • Written by author Wang, Feng
  • Published by Springer-Verlag New York, LLC, 11/9/2010
  • Within the pharmaceutical industry, the improvement of drug discovery and development efficiency and the expected personalization of medicine have become vitally important issues. In Biomarker Methods in Drug Discovery and Development, expert researchers
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Authors

Table of Content

Preface

Contributors

Chapter 1 Biomarker sample collection and handling in the clinical setting to support early phase drug development

Chris B. Russell, Sid Suggs, Kristina M. Robson, Keith Kerkof, Lisa D. Kivman, Kimberly H. Notari, William A. Rees, Natalia Leshinsky, and Scott D. Patterson

Chapter 2 Gene Expression-Based Biomarkers of Drug Safety

Eric A.G. Blomme, and Scott E. Warder

Chapter 3 Profiling Gene Expression Signatures Using Fluorescent Microspheres

Suzanne M. Torontali, Jorge M. Naciff, Kenton D. Juhlin, and Jay P. Tiesman

Chapter 4 Real-Time PCR Gene Expression Assays in Biomarker Discovery and Validation

Yulei Wang, Catalin Barbacioru, David Keys, Pius Brzoska, Caifu Chen, Kelly Li, and Raymond R. Samaha

Chapter 5 SAGE Analysis in Identifying Phenotype SNPs

Sandro J. de Souza, I-Mei Siu, Janete M. Cerutti, and Gregory J. Riggins

Chapter 6 SNP and DNA Methylation Analysis using Pyrosequencing Methods

Jinsheng Yu, and Sharon Marsh

Chapter 7 The Application of LCM for the Analysis of Specific Cell-Type Gene

Expression in a Complex Tissue: the Primate Endometrium

William C. Okulicz

Chapter 8 The use of Two-Dimensional Gel Electrophoresis for Plasma Biomarker Discovery

Brad Jarrold, Alex Varbanov, and Feng Wang

Chapter 9 Difference In Gel Electrophoresis (DIGE), a high resolution protein biomarker research tool

David S. Gibson, David Bramwell, and Caitriona Scaife

Chapter 10 Label-free Mass Spectrometry-based Protein Quantification Technologies in Protein Biomarker Discovery

Mu Wang, Jin-Sam You, Kerry G. Bemis, and Dawn P. G. Fitzpatrick

Chapter 11 Top-Down Quantitative Proteomic Analysis using a Highly Multiplexed Isobaric Mass Tagging Strategy

Bing Xie, Wayne F. Patton, and Craig E. Parman

Chapter 12 SELDI Technology for Identification of Protein Biomarkers

Prasad Devarajan, and Gary F. Ross

Chapter 13 Sandwich ELISA Microarrays: Generating Reliable and Reproducible Assays for High Throughput Screens

Rachel M Gonzalez, Susan M Varnum, and Richard C Zangar

Chapter 14 LC-MS Metabonomics Methodology in Biomarker Discovery

Xin Lu, and Guowang Xu

Chapter 15 GC/MS–based metabolomics

Sally-Ann Fancy, and Klaus Rumpel

Chapter16 NMR-Based Metabolomics for Biomarker Discovery

Narasimhamurthy Shanaiah, Shucha Zhang, M. Aruni Desilva, and Daniel Raftery

Chapter 17 Unraveling Glycerophospholipidomes by Lipidomics

Kim Ekroos

Index


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